Effects of Changyu Daotan Decoction on Depression via Restoration of Mice Hippocampus and Alteration of Expression of Relevant Neurotrophic Factors

Depression, a sort of common psychological disorder, is a serious hazard to people’s health and social progress. Conventional clinical means for this disorder nowadays are mostly chemical medicine treatments accompanied by psychological counseling. Chinese application of using TCM to treat mental di...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2022, Vol.2022, p.5750647-14
Main Authors: Zhang, Suifeng, Chen, Qian, Wu, Lirong, Sun, Ke, Lan, Xiaofang, Xie, Xin, Yan, Junfeng
Format: Article
Language:English
Subjects:
Adaptation
Animals
Antidepressants
Brain-derived neurotrophic factor
Cyclin D1
Experiments
Glial fibrillary acidic protein
Hippocampus
Long-term depression
Mental depression
Mental disorders
Metabolites
Nerve growth factor
Pathogenesis
Sucrose
Traditional Chinese medicine
Wnt protein
β-Catenin
γ-Aminobutyric acid
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Summary:Depression, a sort of common psychological disorder, is a serious hazard to people’s health and social progress. Conventional clinical means for this disorder nowadays are mostly chemical medicine treatments accompanied by psychological counseling. Chinese application of using TCM to treat mental diseases like depression could be traced from hundreds of years ago, in comparison to the long-term depression course and the chemical medicine administration demerits like side effects and resistance, traditional Chinese medicines are milder, more lasting, stable and are the optimal choice for perennial depression treatment. This study was committed to making a comprehensive investigation of Changyu Daotan Decoction’s efficacy in the depression mice model, and it turned out that the Changyu Daotan Decoction was capable of restoring the hippocampus of the depression mice and altering the expressions of neurotrophic factors (the expressions of β-Catenin, cyclin D1 and in GSK-3β BDNF, GFAP, NGF, and Wnt signaling pathways). Results of metabonomics analysis showed that the contents of GABA, His, Tyr, Trp, PA, and 5-HIAA in the mice of the Changyu Daotan Decoction group were restored after administration and showed a conspicuous relevance with the metabolic.
ISSN:1741-427X
1741-4288
DOI:10.1155/2022/5750647