Second primary tumor in patients with upper aerodigestive tract cancer

• Published in: Brazilian journal of otorhinolaryngology 2010-03, Vol.76 (2), p.251-256
• Main Authors: Priante, Antonio Vitor Martins, Carvalho, Andre Lopes, Kowalski, Luiz Paulo
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - therapy; Child; Disease-Free Survival; Female; Follow-Up Studies; head and neck neoplasms; Humans; Incidence; Male; Middle Aged; Mouth Neoplasms - mortality; Mouth Neoplasms - pathology; Mouth Neoplasms - therapy; Neoplasm Staging; neoplasms; Neoplasms, Second Primary - mortality; Neoplasms, Second Primary - pathology; Neoplasms, Second Primary - therapy; Original; Otorhinolaryngologic Neoplasms - mortality; Otorhinolaryngologic Neoplasms - pathology; Otorhinolaryngologic Neoplasms - therapy; Retrospective Studies; second primary tumor; Young Adult
• ISSN: 1808-8694; 1808-8686
• DOI: 10.1590/S1808-86942010000200017

In the first three years after treatment of patients with squamous cell carcinoma of upper aerodigestive tract (UADT), there is a high incidence of recurrences. After the third year, the occurrence of second primary tumor (SPT) is an important cause of morbimortality. To evaluate the incidence and the characteristics of the SPT in patients with squamous cell carcinoma of UADT, treated with curative intention. Retrospective study where the incidence, localization and treatment of SPT had been analyzed and survival rates were calculated. Of the 624 analyzed cases, 59 (9.4%) had SPT during follow-up (4 synchronous and 55 metachronous). The SPT free survival rate ranged from 2 to 191.3 months (median of 42.5 months). In 20 cases (33.9%) the SPT was diagnosed after the fifth year of follow-up. The most frequent site of STP was the UADT mucosa (49.1%), followed by the lungs (22.0%) and the esophagus (11.9%). The best survival after-SPT occurred in cases of UADT STP (32.2% in 5 years, median 16.2 months). The STP incidence was 9.4%. In 33.9% of the cases, the SPT was diagnosed after the fifth year of follow-up. The most frequent localization of STP was the UADT mucosa.