Chloral Hydrate to Study Auditory Brainstem Response

• Published in: Brazilian journal of otorhinolaryngology 2010-07, Vol.76 (4), p.433-436
• Main Authors: Fávero, Mariana Lopes, Sanches Ponce, Fabiana Amaral, Barros Pio, Marcio Ricardo, Tabith, Alfredo, e Silva, Fernando Leite Carvalho
• Format: Article
• Language: English
• Subjects: Child; Child, Preschool; Chloral Hydrate - administration & dosage; Chloral Hydrate - adverse effects; Cross-Sectional Studies; deep sedation; Deep Sedation - methods; Dose-Response Relationship, Drug; evoked potentials; Evoked Potentials, Auditory, Brain Stem; Female; Humans; Hypnotics and Sedatives - administration & dosage; Hypnotics and Sedatives - adverse effects; Infant; Male; Original; pediatrics; Prospective Studies
• ISSN: 1808-8694; 1808-8686
• DOI: 10.1590/S1808-86942010000400005

Chloral Hydrate (CH) is a sedative and hypnotic drug used in pediatric procedures owing to the low depressive effect it has on the respiratory and cardiac systems. To assess the efficacy of the drug in performing ABR and to systematize its use. A prospective cross-sectional study with 41 children without history of heart or lung disease. The initial dose of CH at 10% was 50mg/Kg, with a boost dose of 6mg/Kg administered 30 minutes later in cases in which there was no sedation. Drug effectiveness was established by sleep induction by 1 hour after the administration of the initial dose. Sleep occurrence was correlated with doses (50mg or 56mg/Kg), age, weight and gender. All the 41 children who participated in the study took 50mg/kgof the agent and 23 of them slept within 30 minutes, 2 had respiratory complications, 16 had the 6mg/Kg boost dose and 13 fell asleep after 30 minutes. The 56 mg/kg dose presented a statistically significant effect on sleep induction (p