Plant Viruses: New Opportunities under the Pandemic

During the pandemic, an urgent task has become to develop new vaccine platforms that will help fight the infection caused by SARS-CoV-2 and quickly respond to newly emerging pathogens. Plant viruses can make a significant contribution to the solution of this problem. Phytoviruses, having the propert...

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Bibliographic Details
Published in:Herald of the Russian Academy of Sciences 2022, Vol.92 (4), p.464-469
Main Authors: Karpova, O. V., Nikitin, N. A.
Format: Article
Language:English
Subjects:
Antigens
Chemistry/Food Science
COVID-19
Earth and Environmental Science
Earth Sciences
Engineering
Environment
Immunogenicity
Life Sciences
Pandemics
Scientific Session of the General Meeting of the RAS Members “The Role of Science in Overcoming Pandemics and Postcrisis Development of Society”
Self-assembly
Severe acute respiratory syndrome coronavirus 2
Social Sciences
Tobacco
Vaccines
Viral diseases
Viruses
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Summary:During the pandemic, an urgent task has become to develop new vaccine platforms that will help fight the infection caused by SARS-CoV-2 and quickly respond to newly emerging pathogens. Plant viruses can make a significant contribution to the solution of this problem. Phytoviruses, having the properties of any viral particles (self-assembly, immunogenicity, nanosize), are safe for humans since plants and mammals have no common infectious agents. As a result of thermal rearrangement of the tobacco mosaic virus, spherical particles of a protein nature have been obtained, which have unique immunostimulation and adsorption properties and can play the role of a universal adjuvant platform to create vaccines. Based on these particles, a scheme for obtaining vaccine preparations is proposed. This technology resembles a toy construction set for children. The basis is spherical particles, on the surface of which there are toy blocks—antigens. The “blocks” can be removed, added, or replaced, and this does not take much time and resources. Based on spherical particles, a polyvalent vaccine candidate against COVID-19 has been created as an adjuvant platform.
ISSN:1019-3316
1555-6492
DOI:10.1134/S1019331622040153