A study of the histological behavior of a rabbit vocal fold after a hyaluronic acid injection

The vocal fold structure is composed of tissues with many cells surrounded by the extra-cellular matrix. One of the most important components of the extra-cellular matrix is Hyaluronic Acid (HA). The aim of the study was to evaluate the inflammatory response of rabbit vocal folds after a local injec...

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Bibliographic Details
Published in:Brazilian journal of otorhinolaryngology 2007-03, Vol.73 (2), p.171-178
Main Authors: Lins Perazzo, Paulo Sérgio, de Campos Duprat, André, Lancelotti, Carmem, Donati, Fernanda
Format: Article
Language:English
Subjects:
Animals
Fibrosis - pathology
hoarseness
hyaluronic acid
Hyaluronic Acid - administration & dosage
Hyaluronic Acid - analogs & derivatives
Hyaluronic Acid - pharmacology
inflammatory
Injections
Laryngitis - pathology
Male
Models, Animal
Necrosis - pathology
ocal cord
Original
Rabbits
Random Allocation
Severity of Illness Index
Vocal Cords - drug effects
Vocal Cords - pathology
Vocal Cords - surgery
vocal fold insufficiency
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Summary:The vocal fold structure is composed of tissues with many cells surrounded by the extra-cellular matrix. One of the most important components of the extra-cellular matrix is Hyaluronic Acid (HA). The aim of the study was to evaluate the inflammatory response of rabbit vocal folds after a local injection of Restylane HA. Twelve adult male rabbits randomly received a 0.1 ml injection of Restylane HA in one vocal fold and 0.1 ml of saline in the other vocal fold. The animals were prospectively subdivided into two groups; animals in one group were sacrificed after one week of follow-up and animals in the other group were sacrificed after 3 months. Slides were Hematoxylin-Eosin (HE), Masson Trichromic and Toluidine Blue stained. Hyaluronic Acid was found microscopically in all specimens in both groups. There was more connective tissue surrounding HA, always associated with a mild inflammatory response. The longer exposure time did not increase the intensity of inflammation. Tissue necrosis and foreign body inflammatory reaction were not observed in both groups. The study suggests that HA is a good alternative as a filling material in vocal folds when treating glottal insufficiency.
ISSN:1808-8694
1808-8686
DOI:10.1016/S1808-8694(15)31063-6