The Toxicology Investigators Consortium Case Registry—the 2021 Annual Report

The Toxicology Investigators Consortium (ToxIC) Core Registry was established by the American College of Medical Toxicology in 2010. The Core Registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultations will be entered. This twel...

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Bibliographic Details
Published in:Journal of medical toxicology 2022-10, Vol.18 (4), p.267-296
Main Authors: Love, Jennifer S., Karshenas, Dana L., Spyres, Meghan B., Farrugia, Lynn A., Kang, A. Min, Nguyen, HoanVu, Campleman, Sharan L., Li, Shao, Wax, Paul M., Brent, Jeffery, Aldy, Kim
Format: Article
Language:English
Subjects:
Acetaminophen
Analgesics
Antidotes
Biomedical and Life Sciences
Biomedicine
Consortia
COVID-19
Data collection
Demographics
Demography
Exposure
Fatalities
Fentanyl
Gender
Mortality
Narcotics
Opioids
Original
Original Article
Pandemics
Pharmacology/Toxicology
Signs and symptoms
Toxicology
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Summary:The Toxicology Investigators Consortium (ToxIC) Core Registry was established by the American College of Medical Toxicology in 2010. The Core Registry collects data from participating sites with the agreement that all bedside and telehealth medical toxicology consultations will be entered. This twelfth annual report summarizes the registry’s 2021 data and activity with its additional 8552 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from January 1 to December 31, 2021. Detailed data was collected from these cases and aggregated to provide information, which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. Gender distribution included 50.4% of cases in females, 48.2% of cases in males, and 1.4% of cases in transgender or gender non-conforming individuals. Non-opioid analgesics were the most commonly reported agent class (14.9%), followed by opioids (13.1%). Acetaminophen was the most common agent reported. Fentanyl was the most common opioid reported and was responsible for the greatest number of fatalities. There were 120 fatalities, comprising 1.4% of all cases. Major trends in demographics and exposure characteristics remained similar to past years’ reports. Sub-analyses were conducted to describe new demographic characteristics, including marital status, housing status and military service, the continued COVID-19 pandemic and related toxicologic exposures, and novel substances of exposure.
ISSN:1556-9039
1937-6995
DOI:10.1007/s13181-022-00910-6