MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization

Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. Th...

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Published in:Science advances 2022-09, Vol.8 (36), p.eabn0047-eabn0047
Main Authors: Vondrakova, Jana, Frolikova, Michaela, Ded, Lukas, Cerny, Jiri, Postlerova, Pavla, Palenikova, Veronika, Simonik, Ondrej, Nahacka, Zuzana, Basus, Krystof, Valaskova, Eliska, Machan, Radek, Pacey, Allan, Holubcova, Zuzana, Koubek, Pavel, Ezrova, Zuzana, Park, Soojin, Liu, Ruiwu, Partha, Raghavendran, Clark, Nathan, Neuzil, Jiri, Ikawa, Masahito, Erickson, Kent, Lam, Kit S, Moore, Harry, Komrskova, Katerina
Format: Article
Language:English
Subjects:
Biomedicine and Life Sciences
Developmental Biology
SciAdv r-articles
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Summary:Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.abn0047