Differentiation of Skull Base Chondrosarcomas, Chordomas, and Metastases: Utility of DWI and Dynamic Contrast-Enhanced Perfusion MR Imaging

Differentiation of skull base tumors, including chondrosarcomas, chordomas, and metastases, on conventional imaging remains a challenge. We aimed to test the utility of DWI and dynamic contrast-enhanced MR imaging for skull base tumors. Fifty-nine patients with chondrosarcomas, chordomas, or metasta...

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Published in:American journal of neuroradiology : AJNR 2022-09, Vol.43 (9), p.1325-1332
Main Authors: Ota, Y, Liao, E, Capizzano, A A, Baba, A, Kurokawa, R, Kurokawa, M, Srinivasan, A
Format: Article
Language:English
Subjects:
Chondrosarcoma - diagnostic imaging
Chondrosarcoma - pathology
Chordoma - diagnostic imaging
Chordoma - pathology
Functional
Head & Neck
Humans
Magnetic Resonance Imaging - methods
Male
Middle Aged
Perfusion
Retrospective Studies
Skull Base - pathology
Skull Base Neoplasms - diagnostic imaging
Skull Base Neoplasms - pathology
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Summary:Differentiation of skull base tumors, including chondrosarcomas, chordomas, and metastases, on conventional imaging remains a challenge. We aimed to test the utility of DWI and dynamic contrast-enhanced MR imaging for skull base tumors. Fifty-nine patients with chondrosarcomas, chordomas, or metastases between January 2015 and October 2021 were included in this retrospective study. Pretreatment normalized mean ADC and dynamic contrast-enhanced MR imaging parameters were calculated. The Kruskal-Wallis H test for all tumor types and the Mann-Whitney test for each pair of tumors were used. Fifteen chondrosarcomas (9 men; median age, 62 years), 14 chordomas (6 men; median age, 47 years), and 30 metastases (11 men; median age, 61 years) were included in this study. Fractional plasma volume helped distinguish all 3 tumor types ( = .003,
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.a7607