Fused Cells between Human-Adipose-Derived Mesenchymal Stem Cells and Monocytes Keep Stemness Properties and Acquire High Mobility

Human-adipose-derived mesenchymal stem cells (hADMSCs) are multipotent stem cells which have become of great interest in stem-cell therapy due to their less invasive isolation. However, they have limited migration and short lifespans. Therefore, understanding the mechanisms by which these cells coul...

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Published in:International journal of molecular sciences 2022-08, Vol.23 (17), p.9672
Main Authors: Montalbán-Hernández, Karla, Casado-Sánchez, Cesar, Avendaño-Ortiz, José, Casalvilla-Dueñas, José Carlos, Bonel-Pérez, Gloria C., Prado-Montero, Julia, Valentín-Quiroga, Jaime, Lozano-Rodríguez, Roberto, Terrón-Arcos, Verónica, de la Bastida, Fátima Ruiz, Córdoba, Laura, Laso-García, Fernando, Diekhorst, Luke, del Fresno, Carlos, López-Collazo, Eduardo
Format: Article
Language:English
Subjects:
Adipose tissue
CD14 antigen
Cell culture
Cell therapy
Immunomodulation
Ligands
Mesenchymal stem cells
Microscopy
Monocytes
Regenerative medicine
Stem cells
Tissue engineering
Tumors
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Summary:Human-adipose-derived mesenchymal stem cells (hADMSCs) are multipotent stem cells which have become of great interest in stem-cell therapy due to their less invasive isolation. However, they have limited migration and short lifespans. Therefore, understanding the mechanisms by which these cells could migrate is of critical importance for regenerative medicine. Methods: Looking for novel alternatives, herein, hADMSCs were isolated from adipose tissue and co-cultured with human monocytes ex vivo. Results: A new fused hybrid entity, a foam hybrid cell (FHC), which was CD90+CD14+, resulted from this co-culture and was observed to have enhanced motility, proliferation, immunomodulation properties, and maintained stemness features. Conclusions: Our study demonstrates the generation of a new hybrid cellular population that could provide migration advantages to MSCs, while at the same time maintaining stemness properties.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23179672