Polygenic Risk of Hypertriglyceridemia Is Modified by BMI

Background: Genetic risk scores (GRSs) have partially improved the understanding of the etiology of moderate hypertriglyceridemia (HTG), which until recently was mainly assessed by secondary predisposing causes. The main objective of this study was to assess whether this variability is due to the in...

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Published in:International journal of molecular sciences 2022-08, Vol.23 (17), p.9837
Main Authors: Esteve-Luque, Virginia, Fanlo-Maresma, Marta, Padró-Miquel, Ariadna, Corbella, Emili, Rivas-Regaira, Maite, Pintó, Xavier, Candás-Estébanez, Beatriz
Format: Article
Language:English
Subjects:
Body Mass Index
Body size
Diabetes mellitus
Etiology
Genetic Predisposition to Disease
Genotype
Humans
Hypertriglyceridemia
Hypertriglyceridemia - genetics
Lipoprotein lipase
Metabolic disorders
Metabolism
Multifactorial Inheritance
Obesity
Overweight
Patients
Physical activity
Plasma
Questionnaires
Risk
Transcription Factors - genetics
Triglycerides
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Summary:Background: Genetic risk scores (GRSs) have partially improved the understanding of the etiology of moderate hypertriglyceridemia (HTG), which until recently was mainly assessed by secondary predisposing causes. The main objective of this study was to assess whether this variability is due to the interaction between clinical variables and GRS. Methods: We analyzed 276 patients with suspected polygenic HTG. An unweighted GRS was developed with the following variants: c.724C > G (ZPR1 gene), c.56C > G (APOA5 gene), c.1337T > C (GCKR gene), g.19986711A > G (LPL gene), c.107 + 1647T > C (BAZ1B gene) and g.125478730A > T (TRIB gene). Interactions between the GRS and clinical variables (body mass index (BMI), diabetes mellitus, diet, physical activity, alcohol consumption, age and gender) were evaluated. Results: The GRS was associated with triglyceride (TG) concentrations. There was a significant interaction between BMI and GRS, with the intensity of the relationship between the number of alleles and the TG concentration being greater in individuals with a higher BMI. Conclusions: GRS is associated with plasma TG concentrations and is markedly influenced by BMI. This finding could improve the stratification of patients with a high genetic risk for HTG who could benefit from more intensive healthcare interventions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23179837