Clinical value of YKL‐40 in patients with polymyositis/dermatomyositis: A cross‐sectional study and a systematic review

Introduction We performed a cross‐sectional study to investigate the clinical usefulness of YKL‐40 in patients with dermatomyositis (DM) and conducted a systematic review to summarize the clinical value of YKL‐40 in patients with polymyositis (PM)/DM. Materials and methods A cross‐sectional study an...

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Bibliographic Details
Published in:Journal of clinical laboratory analysis 2022-09, Vol.36 (9), p.e24605-n/a
Main Authors: Cui, Beibei, Chen, Yuehong, Luo, Fengming, Lin, Sang, Liu, Huan, Huang, Yupeng, Zhou, Yueyuan, Tian, Yunru, Yin, Geng, Xie, Qibing
Format: Article
Language:English
Subjects:
Accuracy
biomarker
Chitinase
Cross-sectional studies
Dehydrogenases
Dermatomyositis
Disease
Enrollments
Laboratories
Lung diseases
Medical prognosis
Pathogenesis
Patients
Polymyositis
Proteins
Review
Serum levels
Systematic review
YKL‐40
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Summary:Introduction We performed a cross‐sectional study to investigate the clinical usefulness of YKL‐40 in patients with dermatomyositis (DM) and conducted a systematic review to summarize the clinical value of YKL‐40 in patients with polymyositis (PM)/DM. Materials and methods A cross‐sectional study and a systematic review were performed to study the clinical value of YKL‐40 in patients with PM/DM. Serum YKL‐40 level was detected using enzyme‐linked immunosorbent assay, and its association with clinical and laboratory parameters was analyzed. In the systematic review, electronic databases of OVID Embase, OVID Medline, and web of science were searched to collect studies that reported clinical use of YKL‐40 in patients with PM/DM. Results In the cross‐sectional study, serum YKL‐40 level was higher in patients with DM than in healthy controls (median [interquartile range]: 84.09 [52.72–176.4] ng/ml versus 27.37 [12.30–53.58] ng/ml, p 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24605