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Arylsulfatase I is a prognostic biomarker for head and neck squamous cell carcinoma and Pan‐cancer
Background Sulfatase gene family members mediate various biological functions in tumor stroma and tumor cell environments. However, the expressions and prognostic value of Arylsulfatase I (ARSI), a sulfatase gene family member, in head and neck squamous cell carcinoma (HNSC) have not been fully esta...
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Published in: | Journal of clinical laboratory analysis 2022-09, Vol.36 (9), p.e24600-n/a |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Sulfatase gene family members mediate various biological functions in tumor stroma and tumor cell environments. However, the expressions and prognostic value of Arylsulfatase I (ARSI), a sulfatase gene family member, in head and neck squamous cell carcinoma (HNSC) have not been fully established.
Methods
Arylsulfatase I expressions in pan‐cancer were profiled using publicly available databases. Then, univariate Cox regression, Kaplan–Meier, and the Pearson's correlation analyses were performed to determine correlations between ARSI expressions and cancer prognosis, immune cell status, and drug sensitivity. Gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) were used to assess the potential mechanisms underlying ARSI functions in HNSC.
Results
Arylsulfatase I was highly expressed in 15 cancer types, with significant expressions in HNSC. Elevated ARSI levels were associated with worse prognostic outcomes in HNSC patients. In addition, GSVA and GSEA showed that ARSI was highly involved in tumor cell escape and inflammatory responses. Expressions of ARSI negatively correlated with tumor mutation burden or microsatellite instability and positively correlated with immune‐related genes. Elevated ARSI expressions conferred poor tolerance to daporinad and sinularin, but increased cell sensitivity to dasatinib and XAV939.
Conclusion
Arylsulfatase I is a promising prognostic and therapeutic target for HNSC.
The work flow of the study. TCGA; The Cancer Genome Atlas, GTEx; Genotype‐Tissue Expression, GSVA; Gene Set Variation Analysis, GSEA, Gene Set Enrichment Analysis, ARSI; Arylsulfatase I, MSI; Microsatellite instability, TMB; Tumor mutational burden. |
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ISSN: | 0887-8013 1098-2825 |
DOI: | 10.1002/jcla.24600 |