Comparison of some biochemical markers between early‐onset and late‐onset colorectal precancerous lesions: A single‐center retrospective study

Objective Given that the onset of diseases including colorectal cancer precursors is affecting younger individuals and that obesity is an important risk factor for early‐onset, we conducted a study to explore the biochemical profile of differences in serum between early‐onset patients and late‐onset...

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Published in:Journal of clinical laboratory analysis 2022-09, Vol.36 (9), p.e24637-n/a
Main Authors: Tang, Chao‐Tao, Li, Jun, Yang, Zhenzhen, Zeng, Chunyan, Chen, Youxiang
Format: Article
Language:English
Subjects:
Adenoma
Age
Bilirubin
Biochemical markers
Chi-square test
Cholesterol
Colorectal cancer
colorectal cancer precursor
Colorectal carcinoma
early‐onset
HDL‐C
High density lipoprotein
Kruskal-Wallis test
Laboratories
Lifestyles
lipid metabolism
Lipoproteins
Low density lipoprotein
Metabolism
Obesity
Patients
Polyps
Risk factors
Serology
Surgery
Triglycerides
Tumors
Uric acid
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Summary:Objective Given that the onset of diseases including colorectal cancer precursors is affecting younger individuals and that obesity is an important risk factor for early‐onset, we conducted a study to explore the biochemical profile of differences in serum between early‐onset patients and late‐onset colorectal precancerous lesions. Methods A total of 1447 patients, including 469 early‐onset patients and 978 late‐onset patients, were enrolled from the First Affiliated Hospital of Nanchang University (FAHNU), of which there were 311 sessile serrated adenoma/polyps (SSA/P) and 1136 normal adenomas. The distribution of the included categorical variables was compared via Pearson's chi‐squared test, whereas continuous variables were compared by using the nonparametric Kruskal–Wallis test and ANOVA. Results Compared with late‐onset patients, the levels of total bilirubin and HDL‐C were lower (p 
ISSN:0887-8013
1098-2825
DOI:10.1002/jcla.24637