The Fabrication of Alginate–Carboxymethyl Cellulose-Based Composites and Drug Release Profiles

Recently, hydrogels based on natural water-soluble polysaccharides have attracted more and more attention due to their favorable characteristics. The high water-holding capacity, lack of toxicity, and biodegradability of such hydrogels make it possible to develop new materials on their basis for bio...

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Bibliographic Details
Published in:Polymers 2022-09, Vol.14 (17), p.3604
Main Authors: Morozkina, Svetlana, Strekalovskaya, Ulyana, Vanina, Anna, Snetkov, Petr, Krasichkov, Alexander, Polyakova, Victoriya, Uspenskaya, Mayya
Format: Article
Language:English
Subjects:
Acids
Algae
Beverages
Biocompatibility
Biodegradability
Biomedical engineering
Biomedical materials
Carboxymethyl cellulose
Cellulose
Crosslinked polymers
Crosslinking
Detergents
Drug delivery systems
Efficiency
Food processing industry
Hydrogels
Ice cream
Mechanical properties
Nanoparticles
Natural polymers
Pharmaceuticals
Polymers
Polysaccharides
Reagents
Review
Sodium
Sodium alginate
Toothpaste
Toxicity
Wound healing
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Summary:Recently, hydrogels based on natural water-soluble polysaccharides have attracted more and more attention due to their favorable characteristics. The high water-holding capacity, lack of toxicity, and biodegradability of such hydrogels make it possible to develop new materials on their basis for biotechnological, biomedical, pharmacological, and medical purposes. Sodium alginate is a non-toxic natural polysaccharide found in marine algae. It is capable of forming solid gels under the action of polyvalent cations that cross-link polysaccharide chains. Alginate-based products are popular in many industries, including food processing, pharmaceutical, and biomedical applications. Cellulose is the most abundant, renewable, and natural polymer on Earth, and it is used for various industrial and biomedical applications. Carboxymethyl cellulose (CMC) is useful in pharmaceutical, food, and non-food industries such as tablets, ice cream, drinks, toothpaste, and detergents. In this review, various methods for the preparation of the compositions based on sodium alginate and CMC using different crosslinking agents have been collected for the first time. Additionally, the drug release profile from such polymer matrixes was analyzed.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym14173604