Ischemic Tolerance Induced by Glial Cells

Ischemic tolerance is a phenomenon in which resistance to subsequent invasive ischemia is acquired by a preceding noninvasive ischemic application, and is observed in many organs, including the brain, the organ most vulnerable to ischemic insult. To date, much research has been conducted on cerebral...

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Bibliographic Details
Published in:Neurochemical research 2022-09, Vol.47 (9), p.2522-2528
Main Authors: Koizumi, Schuichi, Hirayama, Yuri
Format: Article
Language:English
Subjects:
Apoptosis
Astrocytes
Biochemistry
Biomedical and Life Sciences
Biomedicine
Blood vessels
Brain diseases
Brain research
Brain-derived neurotrophic factor
Cell Biology
Cytokines
Glial cells
Infections
Ischemia
Microglia
Neurochemistry
Neurology
Neuronal-glial interactions
Neurons
Neurosciences
Original Paper
Tumor necrosis factor-TNF
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Summary:Ischemic tolerance is a phenomenon in which resistance to subsequent invasive ischemia is acquired by a preceding noninvasive ischemic application, and is observed in many organs, including the brain, the organ most vulnerable to ischemic insult. To date, much research has been conducted on cerebral ischemic tolerance as a cell-autonomous action of neurons. In this article, we review the essential roles of microglia and astrocytes in the acquisition of ischemic tolerance through neuron-non-autonomous mechanisms, where the two types of glial cells function in a concerted manner to induce ischemic tolerance.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-022-03704-y