The Edible Plant Crithmum maritimum Shows Nutraceutical Properties by Targeting Energy Metabolism in Hepatic Cancer

In the past few years, evidence has supported the role of plants as a valuable tool for the development of promising therapeutic support options for many diseases, including cancer. We recently discovered that the edible wild plant Crithmum maritimum L. effectively inhibits the growth of hepatocellu...

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Bibliographic Details
Published in:Plant foods for human nutrition (Dordrecht) 2022-09, Vol.77 (3), p.481-483
Main Authors: Gnocchi, Davide, Sabbà, Carlo, Mazzocca, Antonio
Format: Article
Language:English
Subjects:
Acetic acid
Anticancer properties
Cancer
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Crithmum maritimum
Ecology
Energy metabolism
Ethyl acetate
Fermentation
Food Science
Functional foods & nutraceuticals
Glycolysis
Hepatocellular carcinoma
Nutrition
Phenotypes
Plant Physiology
Review
Review Article
Tumors
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Summary:In the past few years, evidence has supported the role of plants as a valuable tool for the development of promising therapeutic support options for many diseases, including cancer. We recently discovered that the edible wild plant Crithmum maritimum L. effectively inhibits the growth of hepatocellular carcinoma (HCC) cells and we provide insights into the biological mechanisms involved. Here, we aimed to characterize the effect of ethyl acetate extract of Crithmum maritimum on the bioenergetic phenotype of HCC cells and if this is associated with the anti-tumour effect we previously described. Results show that Crithmum maritimum significantly increases cellular respiration and reduces lactic fermentation in HCC cells, and that this reduction of the fermentative glycolytic phenotype is linked to inhibition of HCC growth. These data provide new preclinical evidence supporting the role of Crithmum maritimum L. as a nutraceutical option to expand the therapeutic opportunities in the management of HCC.
ISSN:0921-9668
1573-9104
DOI:10.1007/s11130-022-00986-z