Vitamin D Status and VDR Polymorphisms as Prognostic Factors in Differentiated Thyroid Carcinoma

BACKGROUND/AIMVitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in malignant tumors. This study investigated whether vitamin D levels and genetic variations of VDR are risk fact...

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Published in:In vivo (Athens) 2022-09, Vol.36 (5), p.2434-2441
Main Authors: COCOLOS, ANDRA-MARIA, MURESAN, ANDREI, CARAGHEORGHEOPOL, ANDRA, GHEMIGIAN, MIRCEA, IOACHIM, DUMITRU, POIANA, CATALINA
Format: Article
Language:English
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Summary:BACKGROUND/AIMVitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms are involved in a variety of biological processes including cell proliferation, apoptosis, and adhesion in malignant tumors. This study investigated whether vitamin D levels and genetic variations of VDR are risk factors for thyroid cancer. PATIENTS AND METHODSPatients who underwent surgery for differentiated thyroid carcinoma (n=113) and those with benign thyroid pathology (n=150) were genotyped for VDR gene polymorphisms (ApaI, TaqI, FokI, and BsmI) and their 25(OH)D levels were simultaneously measured. Demographic data and histopathologic reports were also acquired for all patients. RESULTSVitamin D levels were significantly lower in the thyroid cancer group (p=0.03). FokI and TaqI polymorphisms were more frequent in the thyroid cancer patients (p
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.12977