Associations of left renal vein entrapment with IgA nephropathy and Henoch-Schönlein purpura nephritis

The aims of the study were to identify whether left renal vein (LRV) entrapment was more prevalent in IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) compared with other types of renal diseases, and the association of LRV entrapment with glomerular incidental IgA and galactose-d...

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Bibliographic Details
Published in:Renal failure 2022-12, Vol.44 (1), p.1520-1528
Main Authors: Wang, Fengmei, Zhu, Huizi, Bao, Shougang, Qi, Hengtao, Xu, Liang, Liu, Xiang, Zhai, Chunjuan, Yang, Xiaowei, Wang, Rong
Format: Article
Language:English
Subjects:
Biopsy
biopsy-proven renal diseases
Body mass index
Clinical Study
Doppler effect
Galactose
Gender
Henoch-Schönlein purpura nephritis
IgA nephropathy
Immunoglobulin A
Kidney diseases
Left renal vein entrapment
Nephritis
Paraffin
Purpura
Schonlein-Henoch purpura
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Summary:The aims of the study were to identify whether left renal vein (LRV) entrapment was more prevalent in IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) compared with other types of renal diseases, and the association of LRV entrapment with glomerular incidental IgA and galactose-deficient-IgA1 (Gd-IgA1) deposition. A total of 797 patients with biopsy-proven kidney diseases have been screened for LRV entrapment by color Doppler ultrasound, and the prevalence of LRV entrapment in different types of renal diseases were then analyzed. Propensity score matching analysis was used to adjust for age, gender, and body mass index. Immunostaining of Gd-IgA1 with KM55 was performed in paraffin-embedded sections of renal biopsy specimens. LRV entrapment was diagnosed in 47 patients (6%) with several kinds of renal diseases in our cohort. A total of 32 (68%) LRV entrapments were combined with expanded IgAN (idiopathic IgAN and HSPN). The prevalence of LRV entrapment in expanded IgAN was significantly higher than that in non-expanded IgAN (17 vs. 2%, p 
ISSN:0886-022X
1525-6049
DOI:10.1080/0886022X.2022.2118065