Susceptibility of caprine mastitis pathogens to tildipirosin, gamithromycin, oxytetracycline, and danofloxacin: effect of serum on the in vitro potency of current macrolides

Mastitis is a significant disease in dairy ruminants, causing economic losses to the livestock industry and severe risks to public health. Antibiotic therapy is one of the most crucial practices to treat mastitis, although the susceptibility of caprine mastitis pathogens to current antibiotics has n...

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Bibliographic Details
Published in:World journal of microbiology & biotechnology 2022-12, Vol.38 (12), p.221-221, Article 221
Main Authors: Galecio, Juan Sebastian, Escudero, Elisa, Corrales, Juan Carlos, García-Romero, Edgar, de la Fe, Christian, Hernandis, Verónica, Marin, Pedro
Format: Article
Language:English
Subjects:
Antibiotics
Applied Microbiology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Coagulase
Culture media
E coli
Economic impact
Environmental Engineering/Biotechnology
Escherichia coli
Goats
Life Sciences
Livestock
Livestock industry
Mastitis
Microbiology
Minimum inhibitory concentration
Oxytetracycline
Pathogens
Public health
Staphylococcus aureus
Streptococcus
Supplements
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Summary:Mastitis is a significant disease in dairy ruminants, causing economic losses to the livestock industry and severe risks to public health. Antibiotic therapy is one of the most crucial practices to treat mastitis, although the susceptibility of caprine mastitis pathogens to current antibiotics has not been tested under standard or modified incubation conditions. This work evaluated the in vitro activity of tildipirosin, gamithromycin, oxytetracycline, and danofloxacin against caprine mastitis pathogens incubated following standard conditions of Clinical and Laboratory Standards Institute (CLSI) and deviation method by 25% supplementation with goat serum. Mycoplasma agalactiae, Escherichia coli, Staphylococcus aureus , Streptococcus spp., and coagulase-negative Staphylococci (CNS) were isolated from dairy goats with mastitis in Spain. Minimum inhibitory concentrations (MICs) were determined using the broth microdilution technique. The lowest MIC 90 under standard conditions was obtained with danofloxacin for mastitis-causing pathogens. An exception was M. agalactiae , where danofloxacin and oxytetracycline obtained low values. However, after adding serum, gamithromycin showed the lowest MIC 50 for S. aureus , Streptococcus spp., and CNS. The lowest MIC 50 was obtained with all the antibiotics tested (
ISSN:0959-3993
1573-0972
DOI:10.1007/s11274-022-03407-0