Bioinformatics analysis of BIRC5 in human cancers

BackgroundAn inhibitor of apoptosis (IAP) family member, baculoviral IAP repeat containing five (BIRC5) plays an important role in the occurrence and development of tumors. However, the underlying mechanism in human cancers remains unclear. MethodsIn this study, we investigated BIRC5 expression and...

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Published in:Annals of translational medicine 2022-08, Vol.10 (16), p.888-888
Main Authors: Ye, Han-Bin, Ma, Bao-Jun, Meng, Gao-Qiang, Tao, Shuo, Wang, Yong, Chen, Zhenghua, Zhao, Wei, Ren, Bing-Yan, Ye, Zi
Format: Article
Language:English
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Summary:BackgroundAn inhibitor of apoptosis (IAP) family member, baculoviral IAP repeat containing five (BIRC5) plays an important role in the occurrence and development of tumors. However, the underlying mechanism in human cancers remains unclear. MethodsIn this study, we investigated BIRC5 expression and explored the prognostic value of BIRC5 in different human cancers via bioinformatics analysis, including the databases of Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, GEPIA, DriverDBv3, GeneMANIA, WEB-based Gene Set Analysis Tool (WebGestalt) and TIMER. ResultsIn most human cancers, BIRC5 usually had higher expression compared to normal human tissues. High expression of BIRC5 could increase the mortality of patients with adrenocortical carcinoma (ACC), kidney renal clear cell carcinoma (KIRC), low-grade glioma (LGG), liver hepatocellular carcinoma (LIHC), and lung adenocarcinoma (LUAD) (P1, P
ISSN:2305-5839
2305-5839
DOI:10.21037/atm-22-3496