Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis

Abstract Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significan...

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Bibliographic Details
Published in:The Journal of infectious diseases 2022-09, Vol.226 (5), p.928-932
Main Authors: Walker, N F, Karim, F, Moosa, M Y S, Moodley, S, Mazibuko, M, Khan, K, Sterling, T R, van der Heijden, Y F, Grant, A D, Elkington, P T, Pym, A, Leslie, A
Format: Article
Language:English
Subjects:
Biomarkers
Brief Report
Collagen (type III)
HIV
Human immunodeficiency virus
Interstitial collagenase
Matrix metalloproteinase
Medical diagnosis
Metalloproteinase
Neutrophil collagenase
Procollagen
Sputum
Stromelysin 2
Tuberculosis
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Summary:Abstract Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity. In this cohort study, plasma matrix metalloproteinase 8 was increased in sputum culture–positive participants at tuberculosis diagnosis and after 6 months of tuberculosis treatment, demonstrating its potential as a biomarker of sputum culture positivity, to enhance tuberculosis treatment monitoring.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiac160