Risk factors for severe infection and mortality in COVID-19 and monoclonal gammopathy of undetermined significance

Two Letters to Blood address the risks of COVID-19 in populations with precursors of hematological disease. In the first article, Miller and colleagues report on whether clonal hematopoiesis of intermediate potential (CHIP) is associated with adverse outcomes with COVID-19, finding no association be...

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Published in:Blood 2022-11, Vol.140 (18), p.1997-2000
Main Authors: Ho, Matthew, Zanwar, Saurabh, Buadi, Francis K., Ailawadhi, Sikander, Larsen, Jeremy, Bergsagel, Leif, Binder, Moritz, Chanan-Khan, Asher, Dingli, David, Dispenzieri, Angela, Fonseca, Rafael, Gertz, Morie A., Gonsalves, Wilson, Go, Ronald S., Hayman, Suzanne, Kapoor, Prashant, Kourelis, Taxiarchis, Lacy, Martha Q., Leung, Nelson, Lin, Yi, Muchtar, Eli, Roy, Vivek, Sher, Taimur, Warsame, Rahma, Fonder, Amie, Hobbs, Miriam, Hwa, Yi L., Kyle, Robert A., Rajkumar, S. Vincent, Kumar, Shaji
Format: Article
Language:English
Subjects:
COVID-19
Humans
Letter to Blood
Monoclonal Gammopathy of Undetermined Significance - complications
Monoclonal Gammopathy of Undetermined Significance - epidemiology
Multiple Myeloma - complications
Paraproteinemias - complications
Risk Factors
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creator Ho, Matthew
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Dingli, David
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Go, Ronald S.
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Kourelis, Taxiarchis
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Lin, Yi
Muchtar, Eli
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Sher, Taimur
Warsame, Rahma
Fonder, Amie
Hobbs, Miriam
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description Two Letters to Blood address the risks of COVID-19 in populations with precursors of hematological disease. In the first article, Miller and colleagues report on whether clonal hematopoiesis of intermediate potential (CHIP) is associated with adverse outcomes with COVID-19, finding no association between CHIP and 28-day mortality while providing data indirectly linking IL-6 signaling and patient outcomes. In the second article, Ho and colleagues investigate the outcomes of patients with monoclonal gammopathy of undetermined significance (MGUS) with COVID-19, reporting that one-fourth had a severe infection and that on multivariable analysis, adverse outcomes are more likely if immunoparesis is present.
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subjects COVID-19
Humans
Letter to Blood
Monoclonal Gammopathy of Undetermined Significance - complications
Monoclonal Gammopathy of Undetermined Significance - epidemiology
Multiple Myeloma - complications
Paraproteinemias - complications
Risk Factors
title Risk factors for severe infection and mortality in COVID-19 and monoclonal gammopathy of undetermined significance
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