Preimplantation genetic testing for aneuploidy in patients with low embryo numbers: benefit or harm?

Purpose We sought to explore the utility of preimplantation genetic testing for aneuploidy (PGT-A) in a poor prognosis group of women with few embryos available for transfer. Methods This was a retrospective matched cohort study examining records for first or second-cycle IVF patients with 1 to 3 bl...

Full description

Saved in:
Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2022-09, Vol.39 (9), p.2027-2033
Main Authors: Mahesan, Arnold M., Chang, Paul T., Ronn, Ruth, Paul, Anthea B. M., Meriano, Jim, Casper, Robert F.
Format: Article
Language:English
Subjects:
Aneuploidy
Assisted Reproduction Technologies
Blastocysts
Embryo transfer
Embryos
Genetic screening
Gynecology
Human Genetics
Medicine
Medicine & Public Health
Reproductive Medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose We sought to explore the utility of preimplantation genetic testing for aneuploidy (PGT-A) in a poor prognosis group of women with few embryos available for transfer. Methods This was a retrospective matched cohort study examining records for first or second-cycle IVF patients with 1 to 3 blastocysts. The study group comprised 130 patients who underwent PGT-A on all embryos. The control group included 130 patients matched by age, BMI, and blastocyst number and quality who did not undergo PGT-A during the same time period. Results The live birth rate (LBR) per embryo transfer (ET) were similar in the PGT-A and control groups, and the spontaneous abortion (SAB) rate was the same (23%). However, we found a significantly higher LBR per oocyte retrieval in the control group vs the PGT-A group (43% vs 20%, respectively) likely due to the many no-euploid cycles in the PGT-A group. In a subgroup analysis for age, the similar LBR per ET persisted in women 
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-022-02588-9