Combining Phenotypes of Nucleotide Excision Repair Pathway to Predict the Risk of Head and Neck Squamous Cell Carcinomas in a Chinese Population

• Published in: Disease markers 2022-09, Vol.2022, p.1-12
• Main Authors: Liang, Yiqian, Zhang, Ling, Chen, Zichen, Chen, Jiayu, Fang, Sui, Zhang, Ting, Zhu, Yun, Liu, Jie, Li, Baiya, Shao, Yuan, Xing, Juanli, Zhang, Shaoqiang, Han, Peng
• Format: Article
• Language: English
• Subjects: Alcohol use; Antibodies; Cancer; Demographic variables; ERCC1 protein; Gene expression; Head and neck carcinoma; Hispanic people; Human papillomavirus; Lymphocytes; Nucleotide excision repair; Nucleotides; Phenotypes; Population; Proteins; Repair; Risk assessment; Smoking; Squamous cell carcinoma; Thermal cycling; White people; XPA protein; XPC protein; XPD protein
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2022/4959737

Background. Nucleotide excision repair (NER) is pivotal in the development of smoking-related malignancies. Nine core genes (XPA, XPB, XPC, XPD, XPF, XPG, ERCC1, DDB1, and DDB2) are highly involved in the NER process. We combined two phenotypes of NER pathway (NER protein and NER gene mRNA expression) and evaluated their associations with the risks of the head and neck squamous cell carcinomas (HNSCCs) in a Chinese population. Methods. We conducted a case-control study of 337 HNSCC patients and 285 cancer-free controls by measuring the expression levels of nine core NER proteins and NER gene mRNA in cultured peripheral lymphocytes. Results. Compared with the controls, cases had statistically significantly lower protein expression levels of XPA (P