Nonalcoholic Fatty Liver Disease and Hypothyroidism: What You Need to Know

Non-alcoholic fatty liver disease (NAFLD) represents one of the leading causes of chronic liver disease globally, perhaps because of the drastic increase in prevalence around the world during the last 20 years and continues growing. The disease starts from simple steatosis (NAFL) that can progress t...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-08, Vol.14 (8), p.e28052-e28052
Main Authors: Bikeyeva, Viktoriya, Abdullah, Ahmed, Radivojevic, Aleksandra, Abu Jad, Anas A, Ravanavena, Anvesh, Ravindra, Chetna, Igweonu-Nwakile, Emmanuelar O, Ali, Safina, Paul, Salomi, Yakkali, Shreyas, Teresa Selvin, Sneha, Thomas, Sonu, Hamid, Pousette
Format: Article
Language:English
Subjects:
Alcohol
Autophagy
Carbohydrates
Cholesterol
Diabetes
Endocrinology/Diabetes/Metabolism
Fatty acids
Gastroenterology
Hepatitis
Hormones
Hypertension
Hypothyroidism
Inflammation
Insulin resistance
Internal Medicine
Lipids
Liver cancer
Liver cirrhosis
Liver diseases
Metabolism
Metabolites
Pathophysiology
Physiology
Proteins
Thyroid gland
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Summary:Non-alcoholic fatty liver disease (NAFLD) represents one of the leading causes of chronic liver disease globally, perhaps because of the drastic increase in prevalence around the world during the last 20 years and continues growing. The disease starts from simple steatosis (NAFL) that can progress to non-alcoholic steatohepatitis (NASH) and, in some patients, progress to cirrhosis and hepatocellular carcinoma (HCC). The pathogenesis and pathophysiology of NAFLD are complex and involve different factors (genetic, metabolic, endocrinopathies, and others). One of the concerns that appeared in recent years is hypothyroidism-induced NAFLD. The pathogenesis is compound and not well understood, and an association between hypothyroidism and NAFLD remains controversial because of insufficient studies that can confirm it. More research is needed to determine the association between hypothyroidism and NAFLD and the underlying mechanisms. In this review, we will discuss a more in-depth analysis of the physiology of thyroid hormones (TH) as well as the pathophysiology of hypothyroidism-induced NAFLD and, based on the recent meta-analyses, the association of thyroid hormones and NAFLD.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.28052