Cardiomyopathy following COVID-19 vaccination in a patient with systemic lupus erythematosus

There are an increasing number of reports of myocarditis associated with mRNA-based COVID-19 vaccination. We describe the case of a female patient with underlying systemic lupus erythematosus, who developed heart failure symptoms following a second dose of the BNT162b2 vaccine. Despite her history o...

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Bibliographic Details
Published in:Modern rheumatology case reports 2023-01, Vol.7 (1), p.87-91
Main Authors: Bhullar, Avreena Kaur, Chew, Zhi Chee, Ong, Ping Seung, Khor, Chiew Gek, Mohd Amin, Nor Hanim
Format: Article
Language:English
Subjects:
BNT162 Vaccine
Case Report
COVID-19 - complications
COVID-19 - prevention & control
COVID-19 Vaccines - adverse effects
Female
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Myocarditis - diagnosis
Myocarditis - etiology
Vaccination - adverse effects
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Summary:There are an increasing number of reports of myocarditis associated with mRNA-based COVID-19 vaccination. We describe the case of a female patient with underlying systemic lupus erythematosus, who developed heart failure symptoms following a second dose of the BNT162b2 vaccine. Despite her history of refractory systemic lupus erythematosus, the disease remained stable after she began rituximab treatment. She underwent serial transthoracic echocardiogram and cardiac magnetic resonance imaging for the evaluation of cardiomyopathy. She showed improvement in cardiac function after treatment with glucocorticoids and intravenous immunoglobulin therapy.
ISSN:2472-5625
2472-5625
DOI:10.1093/mrcr/rxac070