Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

• Published in: Journal of personalized medicine 2022-09, Vol.12 (9), p.1515
• Main Authors: Sharifi-Rad, Javad, Rapposelli, Simona, Sestito, Simona, Herrera-Bravo, Jesús, Arancibia-Diaz, Alejandra, Salazar, Luis A., Yeskaliyeva, Balakyz, Beyatli, Ahmet, Leyva-Gómez, Gerardo, González-Contreras, Carlos, Gürer, Eda Sönmez, Martorell, Miquel, Calina, Daniela
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Animal cognition; Bioactive compounds; Brain research; Dementia; Drugs; Enzymes; FDA approval; Hypotheses; Inflammation; Laboratory animals; Metabolism; Metabolites; Molecular modelling; Neurodegenerative diseases; Neurotoxicity; Oxidative stress; Pathology; Peptides; Phosphorylation; Phytochemicals; Precision medicine; Protein interaction; Proteins; Review; Tau protein; β-Amyloid
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm12091515

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence of Aβ-amyloid peptide, Tau protein, oxidative stress, and an exacerbated neuro-inflammatory response. This review aims to offer an updated compendium of the most recent and promising advances in AD treatment through the administration of phytochemicals. The literature survey was carried out by electronic search in the following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, and Web of Science regarding published works that included molecular mechanisms and signaling pathways targeted by phytochemicals in various experimental models of Alzheimer’s disease in vitro and in vivo. The results of the studies showed that the use of phytochemicals against AD has gained relevance due to their antioxidant, anti-neuroinflammatory, anti-amyloid, and anti-hyperphosphorylation properties of Tau protein. Some bioactive compounds from plants have been shown to have the ability to prevent and stop the progression of Alzheimer’s.