NLRP3 Inflammasome/Pyroptosis: A Key Driving Force in Diabetic Cardiomyopathy

Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM has demanded the attention of medical researchers worldwide. The pathophysiological nature of DCM is intricate, and the ge...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (18), p.10632
Main Authors: Zhang, Lixia, Ai, Chenchen, Bai, Ming, Niu, Jinglei, Zhang, Zheng
Format: Article
Language:English
Subjects:
Apoptosis
Cardiomyopathy
Cardiovascular disease
Caspase-1
Cell death
Cytokines
Diabetes
Diabetes mellitus
Gram-negative bacteria
Heart
Homeostasis
Immune system
Inflammasomes
Inflammatory response
Kinases
Lysis
Medical research
Membranes
Morbidity
Pathogens
Pore formation
Potassium
Pyroptosis
Review
Therapeutic targets
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Summary:Diabetic cardiomyopathy (DCM), a serious diabetic complication, is a kind of low-grade inflammatory cardiovascular disorder. Due to the high risk of morbidity and mortality, DCM has demanded the attention of medical researchers worldwide. The pathophysiological nature of DCM is intricate, and the genesis and development of which are a consequence of the coaction of many factors. However, the exact pathogenesis mechanism of DCM remains unclear. Pyroptosis is a newly identified programmed cell death (PCD) that is directly related to gasdermin D(GSDMD). It is characterized by pore formation on the cell plasma membrane, the release of inflammatory mediators, and cell lysis. The initiation of pyroptosis is closely correlated with NOD-like receptor 3 (NLRP3) activation, which activates caspase-1 and promotes the cleaving of GSDMD. In addition to adjusting the host’s immune defense, NLRP3 inflammasome/pyroptosis plays a critical role in controlling the systemic inflammatory response. Recent evidence has indicated that NLRP3 inflammasome/pyroptosis has a strong link with DCM. Targeting the activation of NLRP3 inflammasome or pyroptosis may be a hopeful therapeutic strategy for DCM. The focus of this review is to summarize the relevant mechanisms of pyroptosis and the relative contributions in DCM, highlighting the potential therapeutic targets in this field.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231810632