Head and Neck Cutaneous Soft-Tissue Sarcoma Demonstrate Sex and Racial/Ethnic Disparities in Incidence and Socioeconomic Disparities in Survival

Background: Cutaneous soft-tissue sarcoma (CSTS) of the head and neck are rare and are known to have aggressive clinical course. The current study utilizes a population-based registry in the U.S. to characterize these malignancies and explore disparities. Methods: National Cancer Institute’s (NCI) S...

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Published in:Journal of clinical medicine 2022-09, Vol.11 (18), p.5475
Main Authors: Jawad, Muhammad Umar, Zeitlinger, Lauren N., Bewley, Arnaud F., O’Donnell, Edmond F., Traven, Sophia A., Carr-Ascher, Janai R., Monjazeb, Arta M., Canter, Robert J., Thorpe, Steven W., Randall, R. Lor
Format: Article
Language:English
Subjects:
Amputation
Biopsy
Cancer therapies
Censuses
Clinical medicine
Codes
Cultural differences
Demographics
Females
Health disparities
Hispanic Americans
Kaposis sarcoma
Medicaid
Medical prognosis
Minority & ethnic groups
Patients
Population
Radiation
Skin
Socioeconomic factors
Statistical analysis
White people
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Summary:Background: Cutaneous soft-tissue sarcoma (CSTS) of the head and neck are rare and are known to have aggressive clinical course. The current study utilizes a population-based registry in the U.S. to characterize these malignancies and explore disparities. Methods: National Cancer Institute’s (NCI) Surveillance, Epidemiology and End Result (SEER) database from 2000 to 2018 was queried to report incidence and survival data in 4253 cases in the U.S. Results: Males were 5.37 times more likely and Non-Hispanic-White people (NHW) were 4.62 times more likely than females and Non-Hispanic-Black people (NHB) to develop CSTS of the head and neck. The overall incidence was 0.27 per 100,000 persons in 2018, with a significant increase since 2000. Advanced age and stage, histologic group other than ‘fibromatous sarcoma’ and lower SES groups were independent factors for worse overall survival. Conclusions: CSTS of the head and neck demonstrate sex and racial/ethnic disparities in incidence and socioeconomic disparities in overall survival. Level of evidence: II.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm11185475