Choriocapillaris Flow Deficits Quantification in Hydroxychloroquine Retinopathy Using Swept-Source Optical Coherence Tomography Angiography

This study aims to quantitatively analyze choriocapillaris (CC) alterations using swept-source optical coherence tomography angiography (SS-OCTA) in eyes presenting with hydroxychloroquine (HCQ) toxic retinopathy and to compare it to patients under HCQ without toxic retinopathy and to healthy contro...

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Bibliographic Details
Published in:Journal of personalized medicine 2022-09, Vol.12 (9), p.1445
Main Authors: Halouani, Safa, Le, Hoang Mai, Cohen, Salomon Yves, Terkmane, Narimane, Herda, Nabil, Souied, Eric H, Miere, Alexandra
Format: Article
Language:English
Subjects:
Age
Angiography
Dermatology
Drug dosages
Hydroxychloroquine
Image processing
Medical imaging
Ophthalmology
Patients
Precision medicine
Retinopathy
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Tomography
Toxicity
Values
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Summary:This study aims to quantitatively analyze choriocapillaris (CC) alterations using swept-source optical coherence tomography angiography (SS-OCTA) in eyes presenting with hydroxychloroquine (HCQ) toxic retinopathy and to compare it to patients under HCQ without toxic retinopathy and to healthy controls. For image analysis, CC en-face slabs were extracted from macular 6 × 6 mm SS-OCTA scans and a compensation method followed by the Phansalkar local thresholding was performed. Percentage of flow deficits (FD%) and other related biomarkers were computed for comparison. Fourteen eyes (7 patients) presenting with HCQ toxic retinopathy, sixty-two eyes (31 patients) under HCQ without signs of toxicity, and sixty eyes of 34 healthy controls were included. With regards to FD%, FD average size, and FD number there was a significant difference between the three groups (p < 0.05 with radius 4 and radius 8 pixels). Eyes presenting with HCQ toxicity had significantly higher FD% and average size, and a significantly lower number of FDs, with both radius 4 and 8 pixels. In conclusion, FD quantification demonstrates that CC involvement is present in HCQ toxic retinopathy, therefore giving pathophysiological insights with regards to the CC as being either the primary or secondary target of HCQ toxicity.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12091445