Clinical Manifestation and Obstetric Outcomes in Pregnant Women with SARS-CoV-2 Infection at Delivery: A Retrospective Cohort Analysis

This retrospective cohort study aimed to analyze the clinical manifestations, complications, and maternal-fetal outcomes in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery. The cohort included 61 pregnant women positive for SARS-CoV-2 infec...

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Bibliographic Details
Published in:Journal of personalized medicine 2022-09, Vol.12 (9), p.1480
Main Authors: Grgić, Gordana, Cerovac, Anis, Hudić, Igor, Laganà, Antonio Simone, Favilli, Alessandro, Garzon, Simone, Chiantera, Vito, Margioula-Siarkou, Chrysoula, Hadžimehmedović, Azra, Mandžić, Amer
Format: Article
Language:English
Subjects:
Antibiotics
Apgar score
Birth weight
Cesarean section
Cohort analysis
Coronaviruses
COVID-19
Disease transmission
Ferritin
Fetuses
Fever
Hospitalization
Hypertension
Infections
Intensive care
Laboratories
Leukocytosis
Lymphopenia
Middle East respiratory syndrome
Neonates
Obstetrics
Patients
Physiology
Pneumonia
Precision medicine
Pregnancy
Premature birth
Respiratory diseases
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Viral infections
Viruses
Womens health
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Summary:This retrospective cohort study aimed to analyze the clinical manifestations, complications, and maternal-fetal outcomes in patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during delivery. The cohort included 61 pregnant women positive for SARS-CoV-2 infection at the time of delivery. Patients were divided into two groups: symptomatic and asymptomatic. We found a significantly higher rate of leukocytosis (p < 0.00078) and lymphopenia (p < 0.0024) in symptomatic women compared with asymptomatic ones. Other laboratory parameters, such as CRP (p = 0.002), AST (p = 0.007), LDH (p = 0.0142), ferritin (p = 0.0036), and D-dimer (p = 0.00124), were also significantly more often increased in the group of symptomatic pregnant women. Overall, symptomatic pregnant women with SARS-CoV-2 infection at the delivery show more often altered laboratory parameters compared with asymptomatic ones; nevertheless, they have a slightly higher but non-significant rate of preterm delivery, cesarean section, as well as lower neonatal birth weight and Apgar score, compared with asymptomatic women.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm12091480