Evaluation of Anti-Candida albicans Activity and Release of Ketoconazole in PMMA-G-PEG 4000 Films

Modified release systems depend on the selection of an appropriate agent capable of controlling the release of the drug, sustaining the therapeutic action over time, and/or releasing the drug at the level of a particular tissue or target organ. Polyethylene glycol 4000 (PEG 4000) is commonly employe...

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Published in:International journal of molecular sciences 2022-09, Vol.23 (18), p.10775
Main Authors: Reynaldo, Juliana Ribeiro, Novack, Kátia Monteiro, Sousa, Lucas Resende Dutra, Vieira, Paula Melo de Abreu, Amparo, Tatiane Roquete, Souza, Gustavo Henrique Bianco de, Teixeira, Luiz Fernando Medeiros, Barboza, Ana Paula Moreira, Neves, Bernardo Ruegger Almeida, Alvarenga, Meiry Edivirges, Martins, Felipe Terra, Santos, Viviane Martins Rebello dos
Format: Article
Language:English
Subjects:
Antifungal agents
Candida albicans
Copolymers
Cytotoxicity
Drug delivery systems
Drugs
Fungal infections
Ketoconazole
Polyethylene glycol
Polymers
Thermogravimetric analysis
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Summary:Modified release systems depend on the selection of an appropriate agent capable of controlling the release of the drug, sustaining the therapeutic action over time, and/or releasing the drug at the level of a particular tissue or target organ. Polyethylene glycol 4000 (PEG 4000) is commonly employed in drug release formulations while polymethyl methacrylate (PMMA) is non-toxic and has a good solubility in organic solvents. This study aimed at the incorporation of ketoconazole in PMMA-g-PEG 4000 and its derivatives, thus evaluating its release profile and anti-Candida albicans and cytotoxic activities. Ketoconazole was characterized and incorporated into the copolymers. The ketoconazole incorporated in the copolymer and its derivatives showed an immediate release profile. All copolymers with ketoconazole showed activity against Candida albicans and were non-toxic to human cells in the entire concentration tested.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231810775