Vitreous Substitutes as Drug Release Systems

Vitreous substitutes are traditionally used to stabilize the retina after vitrectomy. In recent years, various approaches have been developed for using the vitreous substitute not only as a tamponade but also as a drug release system to tackle ocular diseases. This review provides an overview of the...

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Bibliographic Details
Published in:Translational vision science & technology 2022-09, Vol.11 (9), p.14
Main Authors: Schulz, André, Szurman, Peter
Format: Article
Language:English
Subjects:
Drug Liberation
Polymers
Retina
Review
Vitrectomy
Vitreous Body - surgery
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Summary:Vitreous substitutes are traditionally used to stabilize the retina after vitrectomy. In recent years, various approaches have been developed for using the vitreous substitute not only as a tamponade but also as a drug release system to tackle ocular diseases. This review provides an overview of the requirements for vitreous substitutes and discusses the current clinically applied as well as novel polymer-based vitreous substitutes as drug delivery systems, including their release mechanisms, efficiencies, challenges, and future perspectives.
ISSN:2164-2591
2164-2591
DOI:10.1167/tvst.11.9.14