Astrocytes and human artificial blood-brain barrier models

The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells, protecting the central nervous system from potentially harmful substances by selectively controlling the entry of cells and molecules, including components of the immune system. To study the BBB properties, fi...

Full description

Saved in:
Bibliographic Details
Published in:Biomolecules & biomedicine 2022-09, Vol.22 (5), p.651-672
Main Authors: Zidarič, Tanja, Gradišnik, Lidija, Velnar, Tomaž
Format: Article
Language:English
Subjects:
Astrocytes
bioengineering
Biological models
Blood-brain barrier
Design and construction
Health aspects
in vitro models
Physiological aspects
Review
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells, protecting the central nervous system from potentially harmful substances by selectively controlling the entry of cells and molecules, including components of the immune system. To study the BBB properties, find suitable therapies, and identify new drug targets, there is a need to develop representative in vitro BBB models. In this article, we describe the astrocyte roles in the BBB functioning and human in vitro BBB models.
ISSN:1512-8601
2831-0896
1840-4812
2831-090X
DOI:10.17305/bjbms.2021.6943