Extruded small extracellular vesicles: splinters of circulating tumour cells may promote cancer metastasis?

We speculate ruptured circulating tumour cells (CTC) in capillaries could release a large number of small extracellular vesicle-like vesicles, namely mechanically extruded sEV (sEV me ), which can encapsulate chromosomal DNA fragments. These sEV me have similar physicochemical properties compared to...

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Bibliographic Details
Published in:British journal of cancer 2022-10, Vol.127 (7), p.1180-1183
Main Authors: Wan, Yuan, Xia, Yi-Qiu, Zheng, Si-Yang
Format: Article
Language:English
Subjects:
631/67/322
692/308/575
Biomedical and Life Sciences
Biomedical engineering
Biomedicine
Biopsy
Biosynthesis
Blood pressure
Blood vessels
Cancer
Cancer Research
Capillaries
DNA - metabolism
Drug Resistance
Epidemiology
Extracellular vesicles
Extracellular Vesicles - metabolism
Genomes
Humans
Laboratories
Lipids
Membrane proteins
Membrane Proteins - metabolism
Metastases
Metastasis
Molecular Medicine
Morphology
Neoplastic Cells, Circulating - metabolism
Oncogenes
Oncology
Perspective
Physicochemical properties
Proteins
Stem cells
Tumors
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Summary:We speculate ruptured circulating tumour cells (CTC) in capillaries could release a large number of small extracellular vesicle-like vesicles, namely mechanically extruded sEV (sEV me ), which can encapsulate chromosomal DNA fragments. These sEV me have similar physicochemical properties compared to small extracellular vesicles spontaneously secreted by living cells (sEV ss ), and thus sEV me and sEV ss cannot be effectively distinguished based on their size or membrane protein markers. Meanwhile, these sEV me derived from CTC inherit oncogenic payloads, deliver cargo through the bloodstream to recipient cells, and thus may promote cancer metastasis. The validation of this speculation could facilitate our understanding of EV biogenesis and cancer pathology. The potential finding will also provide a theoretical foundation for burgeoning liquid biopsy using DNA fragments derived from harvested sEV.
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-022-01934-z