Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses

Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight...

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Bibliographic Details
Published in:Journal of Equine Science 2022, Vol.33(3), pp.51-54
Main Authors: KURODA, Taisuke, MINAMIJIMA, Yohei, NIWA, Hidekazu, MITA, Hiroshi, TAMURA, Norihisa, FUKUDA, Kentaro, KUWANO, Atsutoshi, SATO, Fumio
Format: Article
Language:English
Subjects:
Aqueous humour
Arthritis
Bacteria
body fluid
Body fluids
Body weight
cephalosporins
Cephalothin
Gram-positive bacteria
Horses
Infectious diseases
Jejunum
Osteomyelitis
Peritoneal fluid
Peritonitis
pharmacokinetics
Pleural fluid
Pleurisy
Staphylococcus aureus
Streptococcus zooepidemicus
Synovial fluid
tissue
Tissues
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Summary:Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC90 values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis.
ISSN:1340-3516
1347-7501
DOI:10.1294/jes.33.51