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Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses
Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight...
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| Published in: | Journal of Equine Science 2022, Vol.33(3), pp.51-54 |
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| Main Authors: | , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c5521-44c616712c612f13f3e6f04466845eed9ec1ba4ff6b50421fbe35e96ccba6c083 |
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| cites | cdi_FETCH-LOGICAL-c5521-44c616712c612f13f3e6f04466845eed9ec1ba4ff6b50421fbe35e96ccba6c083 |
| container_end_page | 54 |
| container_issue | 3 |
| container_start_page | 51 |
| container_title | Journal of Equine Science |
| container_volume | 33 |
| creator | KURODA, Taisuke MINAMIJIMA, Yohei NIWA, Hidekazu MITA, Hiroshi TAMURA, Norihisa FUKUDA, Kentaro KUWANO, Atsutoshi SATO, Fumio |
| description | Cephalothin (CET) concentrations in body fluids (plasma, synovial fluid, pleural fluid, peritoneal fluid, and aqueous humor) and tissue samples (bone, lung, jejunum, hoof, and subcutaneous tissue) were investigated to consider the treatment of infectious diseases in horses. CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC90 values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis. |
| doi_str_mv | 10.1294/jes.33.51 |
| format | article |
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CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC90 values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis.</description><identifier>ISSN: 1340-3516</identifier><identifier>EISSN: 1347-7501</identifier><identifier>DOI: 10.1294/jes.33.51</identifier><language>eng</language><publisher>Utsunomiya-shi: Japanese Society of Equine Science</publisher><subject>Aqueous humour ; Arthritis ; Bacteria ; body fluid ; Body fluids ; Body weight ; cephalosporins ; Cephalothin ; Gram-positive bacteria ; Horses ; Infectious diseases ; Jejunum ; Osteomyelitis ; Peritoneal fluid ; Peritonitis ; pharmacokinetics ; Pleural fluid ; Pleurisy ; Staphylococcus aureus ; Streptococcus zooepidemicus ; Synovial fluid ; tissue ; Tissues</subject><ispartof>Journal of Equine Science, 2022, Vol.33(3), pp.51-54</ispartof><rights>2022 by the Japanese Society of Equine Science</rights><rights>2022. 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CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC90 values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis.</description><subject>Aqueous humour</subject><subject>Arthritis</subject><subject>Bacteria</subject><subject>body fluid</subject><subject>Body fluids</subject><subject>Body weight</subject><subject>cephalosporins</subject><subject>Cephalothin</subject><subject>Gram-positive bacteria</subject><subject>Horses</subject><subject>Infectious diseases</subject><subject>Jejunum</subject><subject>Osteomyelitis</subject><subject>Peritoneal fluid</subject><subject>Peritonitis</subject><subject>pharmacokinetics</subject><subject>Pleural fluid</subject><subject>Pleurisy</subject><subject>Staphylococcus aureus</subject><subject>Streptococcus zooepidemicus</subject><subject>Synovial fluid</subject><subject>tissue</subject><subject>Tissues</subject><issn>1340-3516</issn><issn>1347-7501</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kU1r3DAQhk1poGmSQ_6BoZf24K1GX15fCmVJPyDQS3IWsjxaa_FKW41dyL-vtptuaQ9lxMzAPHqZl6mqW2Ar4J18v0NaCbFS8KK6BCHbplUMXv7qWSMU6FfVa6IdY1wp6C6rx02KDuOc7RxSrJOvHR5GO6V5DLEur0_DU-2nJQxU2zjUcyBasCa7P0xIxw8PY8pp2Y59xqEuPSFdVxfeToQ3z_Wqevx097D50tx_-_x18_G-cUpxaKR0GnQLvBTuQXiB2jMptV5LhTh06KC30nvdKyY5-B6Fwk4711vt2FpcVR9Ouoel3-NwMjKZQw57m59MssH8PYlhNNv0w3SKc82hCLx9Fsjp-4I0m30gh9NkI6aFDG85aNGWKOibf9BdWnIs9grVarFm0LL_U5wBE5If9353olxORBn9eWVg5nhHU-5ohDAK_njc0Wy3eCZtnoOb8Dcpjolz1p4HbrTZYBQ_AQd3p30</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>KURODA, Taisuke</creator><creator>MINAMIJIMA, Yohei</creator><creator>NIWA, Hidekazu</creator><creator>MITA, Hiroshi</creator><creator>TAMURA, Norihisa</creator><creator>FUKUDA, Kentaro</creator><creator>KUWANO, Atsutoshi</creator><creator>SATO, Fumio</creator><general>Japanese Society of Equine Science</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Equine Science</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2022</creationdate><title>Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses</title><author>KURODA, Taisuke ; 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CET 22 mg/kg body weight was intravenously administered to 12 horses. Samples were collected from four different horses at 1, 3, and 5 hr after administration. The CET concentration in body fluids other than aqueous humor was maintained above the MIC90 values of Streptococcus zooepidemicus and Staphylococcus aureus until 5 hr, but it was not maintained above that of S. aureus in bone. CET (22 mg/kg twice a day) is effective for septic arthritis, pleuritis, and peritonitis caused by gram-positive bacteria but ineffective for osteomyelitis.</abstract><cop>Utsunomiya-shi</cop><pub>Japanese Society of Equine Science</pub><doi>10.1294/jes.33.51</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Equine Science, 2022, Vol.33(3), pp.51-54 |
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| subjects | Aqueous humour Arthritis Bacteria body fluid Body fluids Body weight cephalosporins Cephalothin Gram-positive bacteria Horses Infectious diseases Jejunum Osteomyelitis Peritoneal fluid Peritonitis pharmacokinetics Pleural fluid Pleurisy Staphylococcus aureus Streptococcus zooepidemicus Synovial fluid tissue Tissues |
| title | Concentration of cephalothin in body fluids and tissue samples of Thoroughbred horses |
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