Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations

Abstract Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1...

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Bibliographic Details
Published in:Open forum infectious diseases 2022-09, Vol.9 (9), p.ofac472-ofac472
Main Authors: Totten, Arthur H, Uzel, Gulbu, Khil, Pavel P, Youn, Jung-Ho, Treat, Jennifer, Soutar, Craig D, Holland, Steven M, Dekker, John P, Zerbe, Christa S
Format: Article
Language:English
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Brief Report
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Summary:Abstract Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options. Mycoplasma orale is a pathobiont that causes rare disease in immunodeficient hosts. Phosphatidylinositol 3-Kinase, Regulatory Subunit 1 (PI3KR1) mutations predisposes patients to infections and autoimmunity and may be a risk factor for M. orale invasive infections
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofac472