Association of waist circumference with haemoglobin A1c and its optimal cutoff for identifying prediabetes and diabetes risk in the Chinese population

Haemoglobin A1c (HbA1c) is a marker of glycaemic control in type 2 diabetes mellitus (T2DM). Increased waist circumference (WC) is known to be associated with T2DM. Therefore, we investigated the relationship of WC with HbA1c and explored its optimal cutoff for identifying prediabetes and diabetes r...

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Bibliographic Details
Published in:Internal and emergency medicine 2022-10, Vol.17 (7), p.2039-2044
Main Authors: Zhen, Juanying, Liu, Shuyun, Zhao, Guoru, Peng, Hao, Samaranayake, Nithushi, Xu, Aimin, Li, Chao, Wu, Jun, Cheung, Bernard Man Yung
Format: Article
Language:English
Subjects:
Adult
Age
Body Mass Index
Cardiovascular diseases
Child
China - epidemiology
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Entropy
Female
Glycated Hemoglobin
Hemoglobin
Humans
Hypercholesterolemia
Im - Original
Internal Medicine
Male
Medicine
Medicine & Public Health
Obesity
Physical activity
Prediabetic State - diagnosis
Prediabetic State - epidemiology
Risk Factors
Waist Circumference
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Summary:Haemoglobin A1c (HbA1c) is a marker of glycaemic control in type 2 diabetes mellitus (T2DM). Increased waist circumference (WC) is known to be associated with T2DM. Therefore, we investigated the relationship of WC with HbA1c and explored its optimal cutoff for identifying prediabetes and diabetes risk. This study included 2339 participants between 18 and 84 years of age [mean (SD) age, 43.5 (11.9) years] with valid data on WC, HbA1c and related variables in the Shenzhen–Hong Kong United Network on Cardiovascular Disease study. Participants on anti-diabetic medications were excluded. Multiple linear regression was used to investigate the relationship between HbA1c and WC. Cutoff values of WC indicating an HbA1c level of 5.7% and 6.5% were also assessed using optimal binning. There was a significant linear relationship between WC and HbA1c in the overall population ( B  = 0.261, P  
ISSN:1828-0447
1970-9366
DOI:10.1007/s11739-022-03072-z