Malignant oligoastrocytoma in the spinal cord of a cat

A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2022, Vol.84(9), pp.1277-1282
Main Authors: HASEGAWA, Dai, AOSHIMA, Keisuke, SASAOKA, Kazuyoshi, KOBAYASHI, Atsushi, TAKIGUCHI, Mitsuyoshi, KIMURA, Takashi
Format: Article
Language:English
Subjects:
cat
Ki-67
oligoastrocytoma
Pathology
spinal cord
tumor
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Summary:A 12-year and 3-month spayed female mixed cat was presented with severe lumbar pain. Magnetic resonance imaging and postmortem examination revealed a swollen lesion in the spinal cord at L3 level. Histologic examination identified extensive neoplastic cell proliferation with massive necrosis in the tumor tissue. Two types of neoplastic cells were recognized. One type of neoplastic cells were large cells characterized by round to polygonal shape and abundant eosinophilic cytoplasm (referred to as “large cells”). The other neoplastic cells were small, densely proliferated, and had round to irregular shape and scant eosinophilic cytoplasm (referred to as “small cells”). Both types of cells were positive for oligodendrocyte transcription factor 2 and SRY-box transcription factor 10. Glial fibrillary acidic protein was positive in large cells but negative in most small cells. Digital analysis for Ki-67-stained tumor tissues found that total 21.1% ± 6.5% of tumor cells were positive for Ki-67. Based on these findings, we diagnosed malignant oligoastrocytoma in the spinal cord.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.22-0144