Loading…

Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review

Chagas disease is an anthropozoonosis caused by the protozoan Trypanosoma cruzi and is characterized as a neglected disease. It is currently endemic in 21 countries on the Latin American continent, including Bolivia, Argentina, and Paraguay. Unfortunately, there are no optimally effective treatments...

Full description

Saved in:
Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2022-09, Vol.2022, p.1-14
Main Authors: do Carmo Neto, José Rodrigues, Guerra, Rhanoica Oliveira, Rodrigues, Wellington Francisco, da Silva, Marcos Vinicius, Machado, Juliana Reis
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c425t-db2d056e4c0a80afb0dc2a960a0d89cce980aa86fd36c44d7ca83c980dfe7e813
cites cdi_FETCH-LOGICAL-c425t-db2d056e4c0a80afb0dc2a960a0d89cce980aa86fd36c44d7ca83c980dfe7e813
container_end_page 14
container_issue
container_start_page 1
container_title Oxidative medicine and cellular longevity
container_volume 2022
creator do Carmo Neto, José Rodrigues
Guerra, Rhanoica Oliveira
Rodrigues, Wellington Francisco
da Silva, Marcos Vinicius
Machado, Juliana Reis
description Chagas disease is an anthropozoonosis caused by the protozoan Trypanosoma cruzi and is characterized as a neglected disease. It is currently endemic in 21 countries on the Latin American continent, including Bolivia, Argentina, and Paraguay. Unfortunately, there are no optimally effective treatments that can reduce the damage caused in the digestive form of the disease, such as the neuronal destruction of the myenteric plexus of both the esophagus and the colon. Therefore, the objective of this systematic review was to report the possible pharmacological neuroprotective agents that were tested in murine models of the digestive form of Chagas disease. Inclusion criteria are in vivo experimental studies that used different murine models for digestive forms of Chagas disease related to pharmacological interventions with neuroprotective potential, without year and language restriction. On the other hand, the exclusion criteria were studies that did not approach murine models with the digestive form of the disease or did not use neuroprotective treatments, among others. The search in the PubMed, Web of Science, Embase, and LILACS databases was performed on September 4, 2021. In addition, a manual search was performed using the references of the included articles. The risk of bias assessment of the studies was performed based on the SYRCLE tool guidelines, and the data from the selected articles are presented in this review as a narrative description and in tables. Eight articles were included, 4 of which addressed treatment with acetylsalicylic acid, 3 with cyclophosphamide, and 1 with Lycopodium clavatum 13c. In view of the results of the studies, most of them show neuroprotective activity of the treatments, with the potential to reduce the number of damaged neurons, as well as positive changes in the structure of these cells. However, more studies are needed to understand the mechanisms triggered by each drug, as well as their safety and immunogenicity. Systematic review registration is as follows: PROSPERO database (CRD42022289746).
doi_str_mv 10.1155/2022/9397290
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9527410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2720244349</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-db2d056e4c0a80afb0dc2a960a0d89cce980aa86fd36c44d7ca83c980dfe7e813</originalsourceid><addsrcrecordid>eNp9kV9LHDEUxQdpQWv71g8Q8EWwW28ymT_xQZBV24K20NrncDe5sxuZmWyTmVW_fTPdRbAPPiXc88vh3Jws-8jhM-dFcSpAiFOVq0oo2MsOuJJiBkrJN893gP3sXYz3AGUuJD_I2u80Br8OfiAzuA2xu0A4dNQPkTU-sEu3pPhPuPahi8w3bL7CJcakRMJIzPXs6nFNwU2PsGW33lIbz9gF-_UUB-pwcIb9pI2jh_fZ2wbbSB9252H2-_rqbv51dvPjy7f5xc3MSFEMM7sQFoqSpAGsAZsFWCNQlYBga2UMqTTFumxsXhopbWWwzk0a2oYqqnl-mJ1vfdfjoiNrUrCArV6njBietEenXyq9W-ml32hViEpySAbHO4Pg_4zpA3TnoqG2xZ78GLWohMh5UcoJPfoPvfdj6NN6EwVCylyqRH3aUib4GAM1z2E46Kk7PXWnd90l_GSLr1xv8cG9Tv8F4SGbYw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2720244349</pqid></control><display><type>article</type><title>Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review</title><source>Publicly Available Content (ProQuest)</source><source>Wiley Open Access</source><creator>do Carmo Neto, José Rodrigues ; Guerra, Rhanoica Oliveira ; Rodrigues, Wellington Francisco ; da Silva, Marcos Vinicius ; Machado, Juliana Reis</creator><contributor>Alexander, Ivanov ; Ivanov Alexander</contributor><creatorcontrib>do Carmo Neto, José Rodrigues ; Guerra, Rhanoica Oliveira ; Rodrigues, Wellington Francisco ; da Silva, Marcos Vinicius ; Machado, Juliana Reis ; Alexander, Ivanov ; Ivanov Alexander</creatorcontrib><description>Chagas disease is an anthropozoonosis caused by the protozoan Trypanosoma cruzi and is characterized as a neglected disease. It is currently endemic in 21 countries on the Latin American continent, including Bolivia, Argentina, and Paraguay. Unfortunately, there are no optimally effective treatments that can reduce the damage caused in the digestive form of the disease, such as the neuronal destruction of the myenteric plexus of both the esophagus and the colon. Therefore, the objective of this systematic review was to report the possible pharmacological neuroprotective agents that were tested in murine models of the digestive form of Chagas disease. Inclusion criteria are in vivo experimental studies that used different murine models for digestive forms of Chagas disease related to pharmacological interventions with neuroprotective potential, without year and language restriction. On the other hand, the exclusion criteria were studies that did not approach murine models with the digestive form of the disease or did not use neuroprotective treatments, among others. The search in the PubMed, Web of Science, Embase, and LILACS databases was performed on September 4, 2021. In addition, a manual search was performed using the references of the included articles. The risk of bias assessment of the studies was performed based on the SYRCLE tool guidelines, and the data from the selected articles are presented in this review as a narrative description and in tables. Eight articles were included, 4 of which addressed treatment with acetylsalicylic acid, 3 with cyclophosphamide, and 1 with Lycopodium clavatum 13c. In view of the results of the studies, most of them show neuroprotective activity of the treatments, with the potential to reduce the number of damaged neurons, as well as positive changes in the structure of these cells. However, more studies are needed to understand the mechanisms triggered by each drug, as well as their safety and immunogenicity. Systematic review registration is as follows: PROSPERO database (CRD42022289746).</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2022/9397290</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Bias ; Chagas disease ; Esophagus ; Infections ; Intervention ; Laboratory animals ; Mortality ; Review ; Systematic review</subject><ispartof>Oxidative medicine and cellular longevity, 2022-09, Vol.2022, p.1-14</ispartof><rights>Copyright © 2022 José Rodrigues do Carmo Neto et al.</rights><rights>Copyright © 2022 José Rodrigues do Carmo Neto et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 José Rodrigues do Carmo Neto et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-db2d056e4c0a80afb0dc2a960a0d89cce980aa86fd36c44d7ca83c980dfe7e813</citedby><cites>FETCH-LOGICAL-c425t-db2d056e4c0a80afb0dc2a960a0d89cce980aa86fd36c44d7ca83c980dfe7e813</cites><orcidid>0000-0002-8673-7788 ; 0000-0002-5748-5112 ; 0000-0002-2966-7621 ; 0000-0002-3426-2186</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2720244349/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2720244349?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,75126</link.rule.ids></links><search><contributor>Alexander, Ivanov</contributor><contributor>Ivanov Alexander</contributor><creatorcontrib>do Carmo Neto, José Rodrigues</creatorcontrib><creatorcontrib>Guerra, Rhanoica Oliveira</creatorcontrib><creatorcontrib>Rodrigues, Wellington Francisco</creatorcontrib><creatorcontrib>da Silva, Marcos Vinicius</creatorcontrib><creatorcontrib>Machado, Juliana Reis</creatorcontrib><title>Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review</title><title>Oxidative medicine and cellular longevity</title><description>Chagas disease is an anthropozoonosis caused by the protozoan Trypanosoma cruzi and is characterized as a neglected disease. It is currently endemic in 21 countries on the Latin American continent, including Bolivia, Argentina, and Paraguay. Unfortunately, there are no optimally effective treatments that can reduce the damage caused in the digestive form of the disease, such as the neuronal destruction of the myenteric plexus of both the esophagus and the colon. Therefore, the objective of this systematic review was to report the possible pharmacological neuroprotective agents that were tested in murine models of the digestive form of Chagas disease. Inclusion criteria are in vivo experimental studies that used different murine models for digestive forms of Chagas disease related to pharmacological interventions with neuroprotective potential, without year and language restriction. On the other hand, the exclusion criteria were studies that did not approach murine models with the digestive form of the disease or did not use neuroprotective treatments, among others. The search in the PubMed, Web of Science, Embase, and LILACS databases was performed on September 4, 2021. In addition, a manual search was performed using the references of the included articles. The risk of bias assessment of the studies was performed based on the SYRCLE tool guidelines, and the data from the selected articles are presented in this review as a narrative description and in tables. Eight articles were included, 4 of which addressed treatment with acetylsalicylic acid, 3 with cyclophosphamide, and 1 with Lycopodium clavatum 13c. In view of the results of the studies, most of them show neuroprotective activity of the treatments, with the potential to reduce the number of damaged neurons, as well as positive changes in the structure of these cells. However, more studies are needed to understand the mechanisms triggered by each drug, as well as their safety and immunogenicity. Systematic review registration is as follows: PROSPERO database (CRD42022289746).</description><subject>Bias</subject><subject>Chagas disease</subject><subject>Esophagus</subject><subject>Infections</subject><subject>Intervention</subject><subject>Laboratory animals</subject><subject>Mortality</subject><subject>Review</subject><subject>Systematic review</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kV9LHDEUxQdpQWv71g8Q8EWwW28ymT_xQZBV24K20NrncDe5sxuZmWyTmVW_fTPdRbAPPiXc88vh3Jws-8jhM-dFcSpAiFOVq0oo2MsOuJJiBkrJN893gP3sXYz3AGUuJD_I2u80Br8OfiAzuA2xu0A4dNQPkTU-sEu3pPhPuPahi8w3bL7CJcakRMJIzPXs6nFNwU2PsGW33lIbz9gF-_UUB-pwcIb9pI2jh_fZ2wbbSB9252H2-_rqbv51dvPjy7f5xc3MSFEMM7sQFoqSpAGsAZsFWCNQlYBga2UMqTTFumxsXhopbWWwzk0a2oYqqnl-mJ1vfdfjoiNrUrCArV6njBietEenXyq9W-ml32hViEpySAbHO4Pg_4zpA3TnoqG2xZ78GLWohMh5UcoJPfoPvfdj6NN6EwVCylyqRH3aUib4GAM1z2E46Kk7PXWnd90l_GSLr1xv8cG9Tv8F4SGbYw</recordid><startdate>20220925</startdate><enddate>20220925</enddate><creator>do Carmo Neto, José Rodrigues</creator><creator>Guerra, Rhanoica Oliveira</creator><creator>Rodrigues, Wellington Francisco</creator><creator>da Silva, Marcos Vinicius</creator><creator>Machado, Juliana Reis</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8673-7788</orcidid><orcidid>https://orcid.org/0000-0002-5748-5112</orcidid><orcidid>https://orcid.org/0000-0002-2966-7621</orcidid><orcidid>https://orcid.org/0000-0002-3426-2186</orcidid></search><sort><creationdate>20220925</creationdate><title>Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review</title><author>do Carmo Neto, José Rodrigues ; Guerra, Rhanoica Oliveira ; Rodrigues, Wellington Francisco ; da Silva, Marcos Vinicius ; Machado, Juliana Reis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-db2d056e4c0a80afb0dc2a960a0d89cce980aa86fd36c44d7ca83c980dfe7e813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bias</topic><topic>Chagas disease</topic><topic>Esophagus</topic><topic>Infections</topic><topic>Intervention</topic><topic>Laboratory animals</topic><topic>Mortality</topic><topic>Review</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>do Carmo Neto, José Rodrigues</creatorcontrib><creatorcontrib>Guerra, Rhanoica Oliveira</creatorcontrib><creatorcontrib>Rodrigues, Wellington Francisco</creatorcontrib><creatorcontrib>da Silva, Marcos Vinicius</creatorcontrib><creatorcontrib>Machado, Juliana Reis</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>do Carmo Neto, José Rodrigues</au><au>Guerra, Rhanoica Oliveira</au><au>Rodrigues, Wellington Francisco</au><au>da Silva, Marcos Vinicius</au><au>Machado, Juliana Reis</au><au>Alexander, Ivanov</au><au>Ivanov Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><date>2022-09-25</date><risdate>2022</risdate><volume>2022</volume><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Chagas disease is an anthropozoonosis caused by the protozoan Trypanosoma cruzi and is characterized as a neglected disease. It is currently endemic in 21 countries on the Latin American continent, including Bolivia, Argentina, and Paraguay. Unfortunately, there are no optimally effective treatments that can reduce the damage caused in the digestive form of the disease, such as the neuronal destruction of the myenteric plexus of both the esophagus and the colon. Therefore, the objective of this systematic review was to report the possible pharmacological neuroprotective agents that were tested in murine models of the digestive form of Chagas disease. Inclusion criteria are in vivo experimental studies that used different murine models for digestive forms of Chagas disease related to pharmacological interventions with neuroprotective potential, without year and language restriction. On the other hand, the exclusion criteria were studies that did not approach murine models with the digestive form of the disease or did not use neuroprotective treatments, among others. The search in the PubMed, Web of Science, Embase, and LILACS databases was performed on September 4, 2021. In addition, a manual search was performed using the references of the included articles. The risk of bias assessment of the studies was performed based on the SYRCLE tool guidelines, and the data from the selected articles are presented in this review as a narrative description and in tables. Eight articles were included, 4 of which addressed treatment with acetylsalicylic acid, 3 with cyclophosphamide, and 1 with Lycopodium clavatum 13c. In view of the results of the studies, most of them show neuroprotective activity of the treatments, with the potential to reduce the number of damaged neurons, as well as positive changes in the structure of these cells. However, more studies are needed to understand the mechanisms triggered by each drug, as well as their safety and immunogenicity. Systematic review registration is as follows: PROSPERO database (CRD42022289746).</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2022/9397290</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8673-7788</orcidid><orcidid>https://orcid.org/0000-0002-5748-5112</orcidid><orcidid>https://orcid.org/0000-0002-2966-7621</orcidid><orcidid>https://orcid.org/0000-0002-3426-2186</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1942-0900
ispartof Oxidative medicine and cellular longevity, 2022-09, Vol.2022, p.1-14
issn 1942-0900
1942-0994
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9527410
source Publicly Available Content (ProQuest); Wiley Open Access
subjects Bias
Chagas disease
Esophagus
Infections
Intervention
Laboratory animals
Mortality
Review
Systematic review
title Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T04%3A17%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuroprotective%20Treatments%20for%20Digestive%20Forms%20of%20Chagas%20Disease%20in%20Experimental%20Models:%20A%20Systematic%20Review&rft.jtitle=Oxidative%20medicine%20and%20cellular%20longevity&rft.au=do%20Carmo%20Neto,%20Jos%C3%A9%20Rodrigues&rft.date=2022-09-25&rft.volume=2022&rft.spage=1&rft.epage=14&rft.pages=1-14&rft.issn=1942-0900&rft.eissn=1942-0994&rft_id=info:doi/10.1155/2022/9397290&rft_dat=%3Cproquest_pubme%3E2720244349%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c425t-db2d056e4c0a80afb0dc2a960a0d89cce980aa86fd36c44d7ca83c980dfe7e813%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2720244349&rft_id=info:pmid/&rfr_iscdi=true