Balsalazide Exposure During the Development of Fertilizing Sperm May Be Associated With Offspring Birth Defects

Lay Summary We report an association between balsalazide exposure during the development of fertilizing sperm and birth defects in offspring. Exposed offspring were approximately 8 times more likely to have a birth defect. There were no pre-existing reasons to suspect such a relationship, which shou...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2022-10, Vol.28 (10), p.1607-1609
Main Authors: Wensink, Maarten J, Streett, Sarah E, Damkier, Per, Lindahl-Jacobsen, Rune, Kjeldsen, Jens, Eisenberg, Michael L
Format: Article
Language:English
Subjects:
Clinical Brief Reports
Congenital Abnormalities
Humans
Male
Mesalamine
Phenylhydrazines
Semen
Spermatozoa
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Summary:Lay Summary We report an association between balsalazide exposure during the development of fertilizing sperm and birth defects in offspring. Exposed offspring were approximately 8 times more likely to have a birth defect. There were no pre-existing reasons to suspect such a relationship, which should be confirmed in other data.
ISSN:1078-0998
1536-4844
DOI:10.1093/ibd/izac038