Associations of ultra-processed food consumption with cardiovascular disease and all-cause mortality: UK Biobank

Abstract Background This study aimed to investigate the associations between ultra-processed food (UPF) consumption and the risk of cardiovascular disease and all-cause mortality in the UK Biobank Cohort. Methods This observational prospective study evaluated 60 298 participants aged 40 years or old...

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Bibliographic Details
Published in:European journal of public health 2022-10, Vol.32 (5), p.779-785
Main Authors: Chen, Xuanli, Chu, Jiadong, Hu, Wei, Sun, Na, He, Qida, Liu, Siyuan, Feng, Zhaolong, Li, Tongxing, Han, Qiang, Shen, Yueping
Format: Article
Language:English
Subjects:
Biobanks
Biological Specimen Banks
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cerebrovascular diseases
Classification
Coronary artery disease
Diet
Disease
Fast Foods - adverse effects
Fatalities
Food
Food consumption
Food processing
Health risks
Heart diseases
Humans
Mortality
Nutrition
Processed foods
Prospective Studies
Public health
Risk
Risk Factors
Statistical models
United Kingdom - epidemiology
Vascular diseases
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Summary:Abstract Background This study aimed to investigate the associations between ultra-processed food (UPF) consumption and the risk of cardiovascular disease and all-cause mortality in the UK Biobank Cohort. Methods This observational prospective study evaluated 60 298 participants aged 40 years or older. We used the NOVA classification system to identify and categorize UPF. The associations among UPF consumption, cardiovascular disease (CVD) incidence and all-cause mortality were estimated using multivariable Cox proportional hazards models. Dose–response analysis of UPF consumption and CVD incidence and mortality was performed using a restricted cubic spline. Results After a median follow-up of 10.9 years, 6048 participants (10.0%) experienced CVD events, and 5327 (8.8%) and 1503 (2.5%) experienced coronary heart and cerebrovascular diseases, respectively. There were 2590 (4.3%) deaths, of which 384 (0.6%) deaths were caused by CVD. A higher intake of UPF was associated with a higher risk of CVD and all-cause mortality (all P  0.30). Conclusions A higher proportion of UPF consumption was associated with CVD and all-cause mortality. Thus, actions to limit UPF consumption should be incorporated into the CVD and all-cause mortality prevention recommendations.
ISSN:1101-1262
1464-360X
DOI:10.1093/eurpub/ckac104