ARDS in the time of corona: context and perspective

For more than 2 years, COVID-19 has been holding the world at awe with new waves of infections, novel mutants, and still limited (albeit improved) means to combat SARS-CoV-2-induced respiratory failure, the most common and fatal presentation of severe COVID-19. In the present perspective, we draw fr...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2022-10, Vol.323 (4), p.L431-L437
Main Authors: Voelkel, Norbert F., Bogaard, Harm Jan, Kuebler, Wolfgang M.
Format: Article
Language:English
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Summary:For more than 2 years, COVID-19 has been holding the world at awe with new waves of infections, novel mutants, and still limited (albeit improved) means to combat SARS-CoV-2-induced respiratory failure, the most common and fatal presentation of severe COVID-19. In the present perspective, we draw from the successes and—mostly—failures in previous acute respiratory distress syndrome (ARDS) work and the experiences from COVID-19 to define conceptual barriers that have so far hindered therapeutic breakthroughs in this deadly disease, and to open up new avenues of thinking and thus, ultimately of therapy.
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00432.2021