Functional significance of 8-isoprostanes in sinonasal disease and asthma

The purpose of this study was to investigate how 8-isoprostanes, used as a marker of airway oxidative stress, were related to sinus disease and asthma. We analyzed samples and data from two separate studies, one investigating sinonasal disease in asthma, the other investigating the effect of BMI on...

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Bibliographic Details
Published in:Respiratory medicine 2021-08, Vol.185, p.106506-106506, Article 106506
Main Authors: Duchene, Brittany, Caffry, Sarah, Kaminsky, David A., Que, Loretta G., Poynter, Matthew E., Dixon, Anne E.
Format: Article
Language:English
Subjects:
Adult
Asthma - diagnosis
Asthma - etiology
Biomarkers - analysis
Body Mass Index
Dinoprost - analogs & derivatives
Dinoprost - analysis
Female
Humans
Male
Middle Aged
Nasal Lavage Fluid - chemistry
Obesity
Obesity - metabolism
Oxidative Stress
Paranasal Sinus Diseases - diagnosis
Paranasal Sinus Diseases - etiology
Race
Racial Groups
Reactive oxygen species
Young Adult
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Summary:The purpose of this study was to investigate how 8-isoprostanes, used as a marker of airway oxidative stress, were related to sinus disease and asthma. We analyzed samples and data from two separate studies, one investigating sinonasal disease in asthma, the other investigating the effect of BMI on airway disease. We measured airway (nasal lavage) 8-isoprostanes and investigated the relationship with measures of sinus and asthma symptoms, asthma control and lung function. The study of people with sinonasal disease and poorly controlled asthma included 48 obese, 31 overweight and 23 lean participants. In multivariate analysis, nasal lavage 8-isoprostane levels increased with increasing BMI (p 
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2021.106506