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The inhibitory activity of methoxyl flavonoids derived from Inula britannica flowers on SARS-CoV-2 3CLpro

In our ongoing efforts to identify effective natural antiviral agents, four methoxy flavonoids (1–4) were isolated from the Inula britannica flower extract. Their structures were elucidated using nuclear magnetic resonance. Flavonoids 1–4 exhibited inhibitory activity against SARS- CoV-2 3CLpro with...

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Bibliographic Details
Published in:International journal of biological macromolecules 2022-12, Vol.222 (Pt B), p.2098-2104
Main Authors: Kim, Jang Hoon, Park, Yea-In, Hur, Mok, Park, Woo Tae, Moon, Youn-Ho, Koo, Sung Cheol, Yun-Chan, Her, Lee, Ik Soo, Park, Junsoo
Format: Article
Language:English
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Summary:In our ongoing efforts to identify effective natural antiviral agents, four methoxy flavonoids (1–4) were isolated from the Inula britannica flower extract. Their structures were elucidated using nuclear magnetic resonance. Flavonoids 1–4 exhibited inhibitory activity against SARS- CoV-2 3CLpro with IC50 values of 41.6 ± 2.5, 35.9 ± 0.9, 32.8 ± 1.2, and 96.6 ± 3.4 μM, respectively. Flavonoids 1–3 inhibited 3CLpro in a competitive manner. Based on molecular simulations, key amino acids that form hydrogen bond with inhibitor 3 were identified. Finally, we found that inhibitors (1–3) suppressed HCoV-OC43 coronavirus proliferation at micromole concentrations.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2022.10.008