Cysteinyl-tRNA Synthetase 1 Promotes Ferroptosis-Induced Cell Death via Regulating GPX4 Expression

Esophageal squamous cell carcinoma (ESCC) has still been considered to be the most common malignant tumors in China. Emerging evidence indicates that cysteinyl-tRNA synthetase 1 (CARS1) has been considered as a ferroptosis-related gene in ESCC. However, the roles and molecular mechanisms of CARS1 in...

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Published in:Journal of oncology 2022-09, Vol.2022, p.1-16
Main Authors: Zhang, Wanfei, Lin, Xianzuan, Chen, Shaogeng
Format: Article
Language:English
Subjects:
Antibiotics
Apoptosis
Biochemistry
Cancer
Care and treatment
Cell culture
Cell death
Esophageal cancer
Ferroptosis
Investigations
Ligases
Lipid peroxidation
Lipids
Medical prognosis
Reagents
Squamous cell carcinoma
Transfer RNA
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Chen, Shaogeng
description Esophageal squamous cell carcinoma (ESCC) has still been considered to be the most common malignant tumors in China. Emerging evidence indicates that cysteinyl-tRNA synthetase 1 (CARS1) has been considered as a ferroptosis-related gene in ESCC. However, the roles and molecular mechanisms of CARS1 in ferroptosis-induced cell death of ESCC are still largely unknown. In our study, we investigated an aberrantly upregulated gene in ESCC tumor tissues CARS1 significantly inhibited cell proliferation, and the ability of migration and invasion promoted the relative level of MDA and ROS and decreased GPX4 expression level in two ESCC cell lines. Mechanistically, both the ferroptosis inhibitor ferrostatin-1 and its inducer erastin were further used and indicated that CARS1 participated in the ferroptosis-induced cell death. Together, these results revealed that CARS1 has a critical function in the progression of ESCC by promoting ferroptosis-induced cell death.
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subjects Antibiotics
Apoptosis
Biochemistry
Cancer
Care and treatment
Cell culture
Cell death
Esophageal cancer
Ferroptosis
Investigations
Ligases
Lipid peroxidation
Lipids
Medical prognosis
Reagents
Squamous cell carcinoma
Transfer RNA
title Cysteinyl-tRNA Synthetase 1 Promotes Ferroptosis-Induced Cell Death via Regulating GPX4 Expression
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