Use of Immune Checkpoint Inhibitors in Elderly Patients With Chronic Kidney Disease and Renal Cell Carcinoma Metastasis of the Parotid Gland: Case Report and Review of the Literature

Renal cell carcinoma metastasis of the parotid gland is extremely rare, and the present literature review found only 23 cases reported in the last two decades. We present a case of a 75-year-old woman with a colon cancer history who had parotid gland metastasis as the first manifestation of second p...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2022-09, Vol.14 (9)
Main Authors: Parosanu, Andreea, Orlov Slavu, Cristina, Pirlog, Cristina, Stanciu, Ioana M, Nitipir, Cornelia
Format: Article
Language:English
Subjects:
Anemia
Biopsy
Breast cancer
Cancer therapies
Cardiovascular disease
Case reports
Colon
Cytokeratin
Exocrine glands
General Surgery
Immunotherapy
Kidney cancer
Kidney diseases
Leukemia
Medical imaging
Metastasis
Monoclonal antibodies
Older people
Oncology
Otolaryngology
Patients
Scintigraphy
Targeted cancer therapy
Therapeutics
Thyroid gland
Tomography
Tumors
Vertebrae
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Summary:Renal cell carcinoma metastasis of the parotid gland is extremely rare, and the present literature review found only 23 cases reported in the last two decades. We present a case of a 75-year-old woman with a colon cancer history who had parotid gland metastasis as the first manifestation of second primary kidney cancer. The presence of multiple comorbidities affected medical decision-making. Therefore the patient was treated primarily with immunotherapy. After four cycles of dual immune checkpoint blockade, this advanced patient still benefited and was changed to nivolumab monotherapy as maintenance therapy.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.28868