COL11A1 as a potential prognostic target for oral squamous cell carcinoma

• Published in: Medicine (Baltimore) 2022-10, Vol.101 (40), p.e30989-e30989
• Main Authors: Di, Yong-Bin, Bao, Yang, Guo, Jie, Liu, Wei, Zhang, Su-Xin, Zhang, Guan-Hua, Li, Tian-Ke
• Format: Article
• Language: English
• Subjects: Biomarkers, Tumor - metabolism; Carcinoma, Squamous Cell - pathology; Collagen; Collagen Type XI; Head and Neck Neoplasms; Humans; Mouth Neoplasms - pathology; Observational Study; Prognosis; Squamous Cell Carcinoma of Head and Neck
• ISSN: 1536-5964; 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000030989

Oral squamous cell carcinoma (OSCC) is a malignant tumor occurring in the oral cavity. However, the molecular mechanism of OSCC is not clear. Bioinformatics was used to screen and identify role of collagen type X1 alpha 1 (COL11A1) on OSCC. 200 patients with OSCC were recruited. Clinical and follow-up data were recorded and COL11A1 expression levels were tested. Pearson chi-square test and Spearman correlation coefficient were used to analyze relationship between prognosis and related parameters in patients with OSCC. Univariate and multivariate Logistic regression, univariate and multivariate Cox proportional risk regression were used for further analysis, survival curve was drawn. Through bioinformatics analysis, OSCC patients with higher expression of COL11A1 have poor overall survival compare with OSCC patients with lower expression of COL11A1 (hazard ratios [HR] = 1.32, P = .047). Pearson chi-square test showed that age (P = .011), tumor grade (P = .023), COL11A1 (P