Loading…

The evolving epidemiology of monkeypox virus

Monkeypox, caused by the monkeypox virus (MPXV), is a zoonotic disease endemic mainly in West and Central Africa. As of 27 September 2022, human monkeypox has occurred in more than 100 countries (mostly in non-endemic regions) and caused over 66,000 confirmed cases, which differs from previous epide...

Full description

Saved in:
Bibliographic Details
Published in:Cytokine & growth factor reviews 2022-12, Vol.68, p.1-12
Main Authors: Li, Heng, Zhang, Hong, Ding, Ke, Wang, Xiao-Hui, Sun, Gui-Yin, Liu, Zhen-Xing, Luo, Yang
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c467t-34f52193385f08a6d52709f10f51e8be804dbbeb2b233ecd39d96af07394d2573
cites cdi_FETCH-LOGICAL-c467t-34f52193385f08a6d52709f10f51e8be804dbbeb2b233ecd39d96af07394d2573
container_end_page 12
container_issue
container_start_page 1
container_title Cytokine & growth factor reviews
container_volume 68
creator Li, Heng
Zhang, Hong
Ding, Ke
Wang, Xiao-Hui
Sun, Gui-Yin
Liu, Zhen-Xing
Luo, Yang
description Monkeypox, caused by the monkeypox virus (MPXV), is a zoonotic disease endemic mainly in West and Central Africa. As of 27 September 2022, human monkeypox has occurred in more than 100 countries (mostly in non-endemic regions) and caused over 66,000 confirmed cases, which differs from previous epidemics that mainly affected African countries. Due to the increasing number of confirmed cases worldwide, the World Health Organization (WHO) has declared the monkeypox outbreak as a Public Health Emergency of International Concern on July 23, 2022. The international outbreak of human monkeypox represents a novel route of transmission for MPXV, with genital lesions as the primary infection, and the emergence of monkeypox in the current outbreak is also new, as novel variants emerge. Clinical physicians and scientists should be aware of this emerging situation, which presents a different scenario from previous outbreaks. In this review, we will discuss the molecular virology, evasion of antiviral immunity, epidemiology, evolution, and detection of MPXV, as well as prophylaxis and treatment strategies for monkeypox. This review also emphasizes the integration of relevant epidemiological data with genomic surveillance data to obtain real-time data, which could formulate prevention and control measures to curb this outbreak. [Display omitted] •The epidemiology of the current outbreak of human monkeypox have changed.•The genital area is the primary infection site of monkeypox patients.•The lineage B.1 is closely related to the current outbreak of human monkeypox.•The APOBEC3 enzyme is important for MPXV evolution and potential human adaptation.•The transmission of MPXV by primary lesions facilitates the evolution of variants.
doi_str_mv 10.1016/j.cytogfr.2022.10.002
format article
fullrecord <record><control><sourceid>elsevier_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9547435</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1359610122000776</els_id><sourcerecordid>S1359610122000776</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-34f52193385f08a6d52709f10f51e8be804dbbeb2b233ecd39d96af07394d2573</originalsourceid><addsrcrecordid>eNqFkN1KxDAQhYMouK4-gtAHsHWaNG1zo8jiHyx4s16HNpl0s7ZNSbvFvr1ddhG88mqGM3M-OIeQ2xiiGOL0fhepaXCV8REFSmctAqBnZBHnmQiBAT-fd8ZFmM7vl-Sq73cAkDAOC3K32WKAo6tH21YBdlZjY13tqilwJmhc-4VT576D0fp9f00uTFH3eHOaS_L58rxZvYXrj9f31dM6VEmaDSFLDKexYCznBvIi1ZxmIEwMhseYl5hDossSS1pSxlBpJrRICwMZE4mmPGNL8nDkdvuyQa2wHXxRy87bpvCTdIWVfy-t3crKjVLwJJtzzQB-BCjv-t6j-fXGIA-dyZ08dSYPnR3kubPZ93j04ZxutOhlryy2CrX1qAapnf2H8AOnD3lT</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The evolving epidemiology of monkeypox virus</title><source>Elsevier</source><creator>Li, Heng ; Zhang, Hong ; Ding, Ke ; Wang, Xiao-Hui ; Sun, Gui-Yin ; Liu, Zhen-Xing ; Luo, Yang</creator><creatorcontrib>Li, Heng ; Zhang, Hong ; Ding, Ke ; Wang, Xiao-Hui ; Sun, Gui-Yin ; Liu, Zhen-Xing ; Luo, Yang</creatorcontrib><description>Monkeypox, caused by the monkeypox virus (MPXV), is a zoonotic disease endemic mainly in West and Central Africa. As of 27 September 2022, human monkeypox has occurred in more than 100 countries (mostly in non-endemic regions) and caused over 66,000 confirmed cases, which differs from previous epidemics that mainly affected African countries. Due to the increasing number of confirmed cases worldwide, the World Health Organization (WHO) has declared the monkeypox outbreak as a Public Health Emergency of International Concern on July 23, 2022. The international outbreak of human monkeypox represents a novel route of transmission for MPXV, with genital lesions as the primary infection, and the emergence of monkeypox in the current outbreak is also new, as novel variants emerge. Clinical physicians and scientists should be aware of this emerging situation, which presents a different scenario from previous outbreaks. In this review, we will discuss the molecular virology, evasion of antiviral immunity, epidemiology, evolution, and detection of MPXV, as well as prophylaxis and treatment strategies for monkeypox. This review also emphasizes the integration of relevant epidemiological data with genomic surveillance data to obtain real-time data, which could formulate prevention and control measures to curb this outbreak. [Display omitted] •The epidemiology of the current outbreak of human monkeypox have changed.•The genital area is the primary infection site of monkeypox patients.•The lineage B.1 is closely related to the current outbreak of human monkeypox.•The APOBEC3 enzyme is important for MPXV evolution and potential human adaptation.•The transmission of MPXV by primary lesions facilitates the evolution of variants.</description><identifier>ISSN: 1359-6101</identifier><identifier>EISSN: 1879-0305</identifier><identifier>DOI: 10.1016/j.cytogfr.2022.10.002</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Epidemiology ; Evolution ; Monkeypox ; Public health ; Zoonotic disease</subject><ispartof>Cytokine &amp; growth factor reviews, 2022-12, Vol.68, p.1-12</ispartof><rights>2022 Elsevier Ltd</rights><rights>2022 Elsevier Ltd. All rights reserved. 2022 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-34f52193385f08a6d52709f10f51e8be804dbbeb2b233ecd39d96af07394d2573</citedby><cites>FETCH-LOGICAL-c467t-34f52193385f08a6d52709f10f51e8be804dbbeb2b233ecd39d96af07394d2573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Li, Heng</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Ding, Ke</creatorcontrib><creatorcontrib>Wang, Xiao-Hui</creatorcontrib><creatorcontrib>Sun, Gui-Yin</creatorcontrib><creatorcontrib>Liu, Zhen-Xing</creatorcontrib><creatorcontrib>Luo, Yang</creatorcontrib><title>The evolving epidemiology of monkeypox virus</title><title>Cytokine &amp; growth factor reviews</title><description>Monkeypox, caused by the monkeypox virus (MPXV), is a zoonotic disease endemic mainly in West and Central Africa. As of 27 September 2022, human monkeypox has occurred in more than 100 countries (mostly in non-endemic regions) and caused over 66,000 confirmed cases, which differs from previous epidemics that mainly affected African countries. Due to the increasing number of confirmed cases worldwide, the World Health Organization (WHO) has declared the monkeypox outbreak as a Public Health Emergency of International Concern on July 23, 2022. The international outbreak of human monkeypox represents a novel route of transmission for MPXV, with genital lesions as the primary infection, and the emergence of monkeypox in the current outbreak is also new, as novel variants emerge. Clinical physicians and scientists should be aware of this emerging situation, which presents a different scenario from previous outbreaks. In this review, we will discuss the molecular virology, evasion of antiviral immunity, epidemiology, evolution, and detection of MPXV, as well as prophylaxis and treatment strategies for monkeypox. This review also emphasizes the integration of relevant epidemiological data with genomic surveillance data to obtain real-time data, which could formulate prevention and control measures to curb this outbreak. [Display omitted] •The epidemiology of the current outbreak of human monkeypox have changed.•The genital area is the primary infection site of monkeypox patients.•The lineage B.1 is closely related to the current outbreak of human monkeypox.•The APOBEC3 enzyme is important for MPXV evolution and potential human adaptation.•The transmission of MPXV by primary lesions facilitates the evolution of variants.</description><subject>Epidemiology</subject><subject>Evolution</subject><subject>Monkeypox</subject><subject>Public health</subject><subject>Zoonotic disease</subject><issn>1359-6101</issn><issn>1879-0305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkN1KxDAQhYMouK4-gtAHsHWaNG1zo8jiHyx4s16HNpl0s7ZNSbvFvr1ddhG88mqGM3M-OIeQ2xiiGOL0fhepaXCV8REFSmctAqBnZBHnmQiBAT-fd8ZFmM7vl-Sq73cAkDAOC3K32WKAo6tH21YBdlZjY13tqilwJmhc-4VT576D0fp9f00uTFH3eHOaS_L58rxZvYXrj9f31dM6VEmaDSFLDKexYCznBvIi1ZxmIEwMhseYl5hDossSS1pSxlBpJrRICwMZE4mmPGNL8nDkdvuyQa2wHXxRy87bpvCTdIWVfy-t3crKjVLwJJtzzQB-BCjv-t6j-fXGIA-dyZ08dSYPnR3kubPZ93j04ZxutOhlryy2CrX1qAapnf2H8AOnD3lT</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Li, Heng</creator><creator>Zhang, Hong</creator><creator>Ding, Ke</creator><creator>Wang, Xiao-Hui</creator><creator>Sun, Gui-Yin</creator><creator>Liu, Zhen-Xing</creator><creator>Luo, Yang</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20221201</creationdate><title>The evolving epidemiology of monkeypox virus</title><author>Li, Heng ; Zhang, Hong ; Ding, Ke ; Wang, Xiao-Hui ; Sun, Gui-Yin ; Liu, Zhen-Xing ; Luo, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-34f52193385f08a6d52709f10f51e8be804dbbeb2b233ecd39d96af07394d2573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Epidemiology</topic><topic>Evolution</topic><topic>Monkeypox</topic><topic>Public health</topic><topic>Zoonotic disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Heng</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Ding, Ke</creatorcontrib><creatorcontrib>Wang, Xiao-Hui</creatorcontrib><creatorcontrib>Sun, Gui-Yin</creatorcontrib><creatorcontrib>Liu, Zhen-Xing</creatorcontrib><creatorcontrib>Luo, Yang</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cytokine &amp; growth factor reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Heng</au><au>Zhang, Hong</au><au>Ding, Ke</au><au>Wang, Xiao-Hui</au><au>Sun, Gui-Yin</au><au>Liu, Zhen-Xing</au><au>Luo, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The evolving epidemiology of monkeypox virus</atitle><jtitle>Cytokine &amp; growth factor reviews</jtitle><date>2022-12-01</date><risdate>2022</risdate><volume>68</volume><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1359-6101</issn><eissn>1879-0305</eissn><abstract>Monkeypox, caused by the monkeypox virus (MPXV), is a zoonotic disease endemic mainly in West and Central Africa. As of 27 September 2022, human monkeypox has occurred in more than 100 countries (mostly in non-endemic regions) and caused over 66,000 confirmed cases, which differs from previous epidemics that mainly affected African countries. Due to the increasing number of confirmed cases worldwide, the World Health Organization (WHO) has declared the monkeypox outbreak as a Public Health Emergency of International Concern on July 23, 2022. The international outbreak of human monkeypox represents a novel route of transmission for MPXV, with genital lesions as the primary infection, and the emergence of monkeypox in the current outbreak is also new, as novel variants emerge. Clinical physicians and scientists should be aware of this emerging situation, which presents a different scenario from previous outbreaks. In this review, we will discuss the molecular virology, evasion of antiviral immunity, epidemiology, evolution, and detection of MPXV, as well as prophylaxis and treatment strategies for monkeypox. This review also emphasizes the integration of relevant epidemiological data with genomic surveillance data to obtain real-time data, which could formulate prevention and control measures to curb this outbreak. [Display omitted] •The epidemiology of the current outbreak of human monkeypox have changed.•The genital area is the primary infection site of monkeypox patients.•The lineage B.1 is closely related to the current outbreak of human monkeypox.•The APOBEC3 enzyme is important for MPXV evolution and potential human adaptation.•The transmission of MPXV by primary lesions facilitates the evolution of variants.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.cytogfr.2022.10.002</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1359-6101
ispartof Cytokine & growth factor reviews, 2022-12, Vol.68, p.1-12
issn 1359-6101
1879-0305
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9547435
source Elsevier
subjects Epidemiology
Evolution
Monkeypox
Public health
Zoonotic disease
title The evolving epidemiology of monkeypox virus
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T00%3A46%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20evolving%20epidemiology%20of%20monkeypox%20virus&rft.jtitle=Cytokine%20&%20growth%20factor%20reviews&rft.au=Li,%20Heng&rft.date=2022-12-01&rft.volume=68&rft.spage=1&rft.epage=12&rft.pages=1-12&rft.issn=1359-6101&rft.eissn=1879-0305&rft_id=info:doi/10.1016/j.cytogfr.2022.10.002&rft_dat=%3Celsevier_pubme%3ES1359610122000776%3C/elsevier_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c467t-34f52193385f08a6d52709f10f51e8be804dbbeb2b233ecd39d96af07394d2573%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true